Serum oxidative stress level correlates with clinical parameters in chronic systolic heart failure patients

Offer Amir, Hagar Paz, Ori Rogowski, Marina Barshai, Moran Sagiv, Sergei Shnizer, Abraham Z. Reznick, Ruthie E. Amir

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Background: Serum oxidative stress (OS) level has an important role in the inflammatory process of heart failure. Hypothesis: The study was designed to analyze serum OS levels in chronic heart failure (HF) patients and to examine the relation between OS levels and other clinical and prognostic parameters of HF. Methods: We studied 82 consecutive chronic symptomatic HF patients with systolic LV dysfunction (ejection fraction < 45%). The serum OS level was determined using thermochemiluminescence assay. We compared the serum OS levels with patients' clinical and prognostic parameters. Results: Higher serum OS levels were associated with higher New York Heart Association class (P = .01), worse renal function (serum urea, creatinine, and creatinine clearance) (P<.001) and higher serum levels of hs-C-reactive protein and N-terminal pro brain natriuretic peptide (P = .001, P<.001, respectively). Conclusions: In chronic systolic HF patients, high serum OS levels correlate with advanced disease and known markers of poor prognosis.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalClinical Cardiology
Volume32
Issue number4
DOIs
StatePublished - Apr 2009
Externally publishedYes

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