Serum insulin-like growth factors I and II are not affected by undernutrition in children with nonorganic failure to thrive

Moshe Phillip, Eli Hershkovitz, Hector Rosenblum, Inbal Savion, Yael Segev, Jacob Levy, Drora Frazer

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of our study was to determine the serum levels of IGF-I, IGF-II, and their binding proteins IGFBP-1 and IGFBP-3 in young children 3 months to 2 years of age with nonorganic failure to thrive (NOFTT). 29 children with NOFTT and 32 normal controls were recruited and studied for auxologic and hormonal parameters. The NOFTT group had significantly higher serum concentrations of IGFBP-1 than the control group: 57.7 ± 18 vs. 48 ± 19 μg/l (p < 0.05). IGF-I and IGF-II serum levels were highly correlated to serum IGFBP-3 but there were no differences in the serum IGF-I, IGF-II and IGFBP-3 levels between the groups. We conclude that IGF-I, IGF-II, and IGFBP-3 are not useful for the evaluation of nutritional status in children, under the age of 2 years, with NOFTT.

Original languageEnglish
Pages (from-to)76-79
Number of pages4
JournalHormone Research
Volume49
Issue number2
DOIs
StatePublished - Feb 1998
Externally publishedYes

Keywords

  • Infant
  • Insulin-like growth factor binding proteins 1 and 3
  • Insulin-like growth factors I and II
  • Nonorganic failure to thrive

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