Serum homocysteine and long-term risk of myocardial infarction and sudden death in patients with coronary heart disease

Moti Haim; David Tanne; Uri Goldbourt; Ram Doolman; Valentina Boyko; Daniel Brunner; Ben Ami Sela; Solomon Behar

doi:10.1159/000093697

Serum homocysteine and long-term risk of myocardial infarction and sudden death in patients with coronary heart disease

Moti Haim^*, David Tanne, Uri Goldbourt, Ram Doolman, Valentina Boyko, Daniel Brunner, Ben Ami Sela, Solomon Behar

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We have prospectively evaluated the risk of incident coronary events in association with serum total homocysteine in patients with preexisting chronic coronary heart disease. A nested case-control design was used. Total homocysteine concentration was measured in baseline fasting serum samples from patients with chronic coronary heart disease enrolled in the Bezafibrate Infarction Prevention Study (n = 3,090) who developed coronary events during 6.2 years of follow-up (n = 69). They were matched for age and gender with controls without subsequent cardiovascular events. Elevated homocysteine levels were associated with 2.5 times higher risk of subsequent coronary events and each 5 μmol/l increment was associated with a 25% higher risk.

Original language	English
Pages (from-to)	52-56
Number of pages	5
Journal	Cardiology
Volume	107
Issue number	1
DOIs	https://doi.org/10.1159/000093697
State	Published - Dec 2006

Keywords

Homocysteine
Myocardial infarction
Risk factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000093697

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abstract = "We have prospectively evaluated the risk of incident coronary events in association with serum total homocysteine in patients with preexisting chronic coronary heart disease. A nested case-control design was used. Total homocysteine concentration was measured in baseline fasting serum samples from patients with chronic coronary heart disease enrolled in the Bezafibrate Infarction Prevention Study (n = 3,090) who developed coronary events during 6.2 years of follow-up (n = 69). They were matched for age and gender with controls without subsequent cardiovascular events. Elevated homocysteine levels were associated with 2.5 times higher risk of subsequent coronary events and each 5 μmol/l increment was associated with a 25% higher risk.",

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AU - Boyko, Valentina

AU - Brunner, Daniel

AU - Sela, Ben Ami

AU - Behar, Solomon

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AB - We have prospectively evaluated the risk of incident coronary events in association with serum total homocysteine in patients with preexisting chronic coronary heart disease. A nested case-control design was used. Total homocysteine concentration was measured in baseline fasting serum samples from patients with chronic coronary heart disease enrolled in the Bezafibrate Infarction Prevention Study (n = 3,090) who developed coronary events during 6.2 years of follow-up (n = 69). They were matched for age and gender with controls without subsequent cardiovascular events. Elevated homocysteine levels were associated with 2.5 times higher risk of subsequent coronary events and each 5 μmol/l increment was associated with a 25% higher risk.

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Serum homocysteine and long-term risk of myocardial infarction and sudden death in patients with coronary heart disease

Abstract

Keywords

UN SDGs

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