Serum concentrations of isosorbide dinitrate produced by a sustained-release capsule

H. Halkin, S. Almog, E. Friedman

Research output: Contribution to journalArticlepeer-review

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Abstract

The bioavailability of isosorbide dinitrate (ISDN) and the time course of its serum concentration produced by a standard 20-mg tablet and a sustained-release capsule were compared in six normal volunteers. Following administration of the tablet, serum ISDN concentrations reached a peak of 29 ng/ml at 0.5 hr, declined monoexponentially with a t 1/2 of 25.5 min, and disappeared after 2 to 3 hr. Following the administration of the sustained-release capsule, serum ISDN concentrations reached a plateau of 4 ng/ml between 2 and 5 hr, and declined slowly and non-linearly up to and including the 10-hr point. The total amount of ISDN absorbed was 1.32 times greater with the standard tablet; following the absorption of the capsule, there was truncation of the serum concentration curve due to ongoing absorption at and beyond 10 hr.

Original languageEnglish
Pages (from-to)448-450
Number of pages3
JournalIsrael Journal of Medical Sciences
Volume15
Issue number5
StatePublished - 1979
Externally publishedYes

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