Serum concentrations of interleukin-2R (IL-2R), IL-6, IL-8, and tumor necrosis factor alpha in patients with ectopic pregnancy

David Soriano, Danielle Hugol, Nhuan Tran Quang, Emile Darai

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate the diagnostic relevance of serum cytokine concentrations in ectopic pregnancy (EP). Design: Cohort study. Setting: University hospital. Patient(s): Seventeen women with EP, 22 women with miscarriage, and 33 women with normal intrauterine pregnancy, at comparable stages of gestation. Intervention(s): Interleukin (IL)-2 receptor, IL-6, IL-8, and tumor necrosis factor alpha (TNF-α) determination by immunoradiometric assay. Main Outcome Measure(s): Serum concentrations of progesterone, β-hCG, IL-2R, IL-6, IL-8, and TNF-α. Result(s): Serum levels of IL-6 were higher in women with EP than in those with miscarriage and normal pregnancy. Serum levels of TNF-α were higher in women with EP than in those with miscarriage and normal pregnancy. Serum levels of IL-8 were higher in women with EP than in those with miscarriage and normal pregnancy. An IL-8 cutoff of >40 pg/mL predicted EP with a sensitivity of 82.4%, a specificity of 81.8%, and positive and negative predictive values of 58.3% and 93.8%. No difference in serum IL-2R levels was found among the groups. Conclusion(s): Serum IL-8, IL-6, and TNF-α concentrations are higher in women with EP than in those with miscarriage and normal pregnancy. Further studies are needed to determine their diagnostic value.

Original languageEnglish
Pages (from-to)975-980
Number of pages6
JournalFertility and Sterility
Volume79
Issue number4
DOIs
StatePublished - 1 Apr 2003
Externally publishedYes

Keywords

  • Cytokine
  • Ectopic pregnancy
  • Interleukin
  • Miscarriage
  • Tumor necrosis factor

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