Serum CA-125 levels were measured in patients who suffer from familial Mediterranean fever (FMF) during acute attack and during attack-free period. All forms of peritonitis previously examined showed a significant rise in serum CA-125 levels. The mean CA-125 levels during acute FMF attack was 10.9 u/ml, in attack-free periods of 4.4 u/ml. The mean CA-125 value of the control group was 13.6 u/ml. All sera measured (except one - 47 u/ml) were within normal range - below 30 u/ml. This observation is in contradiction to what was previously reported that in peritonitis from other causes, infective and non-infective CA-125 levels are markedly elevated above normal range in most patients. It may be suggested that the mesothelium - the tissue layer that secretes CA-125 during inflammation - is not involved in the inflammatory reaction of FMF peritonitis as during classical peritonitis. These differences in mesothelial involvement might explain some of the clinical and pathological differences between FMF peritonitis and other causes of peritonitis.
|Number of pages||7|
|Journal||Journal of Tumor Marker Oncology|
|State||Published - 1991|