Serum bioactive and immunoreactive follicle stimulating hormone during chronic treatment with gonadotropin releasing hormone agonist in elderly men

H. Matzkin, Z. Braf, N. Dekel

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic administration of GnRH agonists 'down regulates' the pituitary and decreases LH and FSH serum levels. Changes in the bioactivity of FSH have not been adequately assessed under such treatment, for lack of a proper test. We examined serum changes under GnRH agonist treatment among 12 healthy elderly men suffering only from benign prostatic hypertrophy, for up to one year, using a modification of a granulosa cell bioassay for the determination of FSH bioactivity. While radioimmunoassay-FSH decreased, we noticed a significant increase in the bioactivity of this hormone. The clinical importance of this increase is discussed.

Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalHormone and Metabolic Research
Volume23
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

Keywords

  • FSH
  • FSH-Bioactivity
  • GnRH

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