Serum amyloid A-derived peptides, present in human rheumatic synovial fluids, induce the secretion of interferon-γ by human CD4+ T-lymphocytes

Eran J. Yavin, Liana Preciado-Patt, Oren Rosen, Michael Yaron, Roderich D. Suessmuth, David Levartowsky, Gunther Jung, Ofer Lider, Mati Fridkin

Research output: Contribution to journalArticlepeer-review

Abstract

Serum amyloid A (SAA) is a major acute-phase protein whose biochemical functions remain largely obscure. Human rheumatic synovial fluids were screened by high performance liquid chromatography mass spectrometry for SAA-derived peptides, specifically the sequence AGLPEKY (SAA98-104) which was previously shown to modulate various leukocyte functions. Two such fluids were found to contain a truncated version of SAA98-104. Synthetic SAA98-104 and several of its analogs were shown capable of binding isolated human CD4+ T-lymphocytes and stimulating them to produce interferon-γ. Given the high acute-phase serum level of SAA and its massive proteolysis by inflammatory related enzymes, SAA-derived peptides may be involved in host defense mechanisms. Copyright (C) 2000 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalFEBS Letters
Volume472
Issue number2-3
DOIs
StatePublished - 28 Apr 2000
Externally publishedYes

Keywords

  • Inflammation
  • Interferon-γ
  • Serum amyloid A
  • T-lymphocyte

Fingerprint

Dive into the research topics of 'Serum amyloid A-derived peptides, present in human rheumatic synovial fluids, induce the secretion of interferon-γ by human CD4+ T-lymphocytes'. Together they form a unique fingerprint.

Cite this