Serum amyloid A-derived peptides, present in human rheumatic synovial fluids, induce the secretion of interferon-γ by human CD4+ T-lymphocytes

Eran J. Yavin; Liana Preciado-Patt; Oren Rosen; Michael Yaron; Roderich D. Suessmuth; David Levartowsky; Gunther Jung; Ofer Lider; Mati Fridkin

doi:10.1016/S0014-5793(00)01470-8

Serum amyloid A-derived peptides, present in human rheumatic synovial fluids, induce the secretion of interferon-γ by human CD₄⁺ T-lymphocytes

Eran J. Yavin, Liana Preciado-Patt, Oren Rosen, Michael Yaron, Roderich D. Suessmuth, David Levartowsky, Gunther Jung, Ofer Lider, Mati Fridkin

Research output: Contribution to journal › Article › peer-review

Abstract

Serum amyloid A (SAA) is a major acute-phase protein whose biochemical functions remain largely obscure. Human rheumatic synovial fluids were screened by high performance liquid chromatography mass spectrometry for SAA-derived peptides, specifically the sequence AGLPEKY (SAA_98-104) which was previously shown to modulate various leukocyte functions. Two such fluids were found to contain a truncated version of SAA_98-104. Synthetic SAA_98-104 and several of its analogs were shown capable of binding isolated human CD₄⁺ T-lymphocytes and stimulating them to produce interferon-γ. Given the high acute-phase serum level of SAA and its massive proteolysis by inflammatory related enzymes, SAA-derived peptides may be involved in host defense mechanisms. Copyright (C) 2000 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	259-262
Number of pages	4
Journal	FEBS Letters
Volume	472
Issue number	2-3
DOIs	https://doi.org/10.1016/S0014-5793(00)01470-8
State	Published - 28 Apr 2000
Externally published	Yes

Keywords

Inflammation
Interferon-γ
Serum amyloid A
T-lymphocyte

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10.1016/S0014-5793(00)01470-8

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title = "Serum amyloid A-derived peptides, present in human rheumatic synovial fluids, induce the secretion of interferon-γ by human CD4+ T-lymphocytes",

abstract = "Serum amyloid A (SAA) is a major acute-phase protein whose biochemical functions remain largely obscure. Human rheumatic synovial fluids were screened by high performance liquid chromatography mass spectrometry for SAA-derived peptides, specifically the sequence AGLPEKY (SAA98-104) which was previously shown to modulate various leukocyte functions. Two such fluids were found to contain a truncated version of SAA98-104. Synthetic SAA98-104 and several of its analogs were shown capable of binding isolated human CD4+ T-lymphocytes and stimulating them to produce interferon-γ. Given the high acute-phase serum level of SAA and its massive proteolysis by inflammatory related enzymes, SAA-derived peptides may be involved in host defense mechanisms. Copyright (C) 2000 Federation of European Biochemical Societies.",

keywords = "Inflammation, Interferon-γ, Serum amyloid A, T-lymphocyte",

author = "Yavin, {Eran J.} and Liana Preciado-Patt and Oren Rosen and Michael Yaron and Suessmuth, {Roderich D.} and David Levartowsky and Gunther Jung and Ofer Lider and Mati Fridkin",

year = "2000",

month = apr,

day = "28",

doi = "10.1016/S0014-5793(00)01470-8",

language = "אנגלית",

volume = "472",

pages = "259--262",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Wiley-Blackwell",

number = "2-3",

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Serum amyloid A-derived peptides, present in human rheumatic synovial fluids, induce the secretion of interferon-γ by human CD₄⁺ T-lymphocytes. / Yavin, Eran J.; Preciado-Patt, Liana; Rosen, Oren; Yaron, Michael; Suessmuth, Roderich D.; Levartowsky, David; Jung, Gunther; Lider, Ofer; Fridkin, Mati.

In: FEBS Letters, Vol. 472, No. 2-3, 28.04.2000, p. 259-262.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Serum amyloid A-derived peptides, present in human rheumatic synovial fluids, induce the secretion of interferon-γ by human CD4+ T-lymphocytes

AU - Yavin, Eran J.

AU - Preciado-Patt, Liana

AU - Rosen, Oren

AU - Yaron, Michael

AU - Suessmuth, Roderich D.

AU - Levartowsky, David

AU - Jung, Gunther

AU - Lider, Ofer

AU - Fridkin, Mati

PY - 2000/4/28

Y1 - 2000/4/28

N2 - Serum amyloid A (SAA) is a major acute-phase protein whose biochemical functions remain largely obscure. Human rheumatic synovial fluids were screened by high performance liquid chromatography mass spectrometry for SAA-derived peptides, specifically the sequence AGLPEKY (SAA98-104) which was previously shown to modulate various leukocyte functions. Two such fluids were found to contain a truncated version of SAA98-104. Synthetic SAA98-104 and several of its analogs were shown capable of binding isolated human CD4+ T-lymphocytes and stimulating them to produce interferon-γ. Given the high acute-phase serum level of SAA and its massive proteolysis by inflammatory related enzymes, SAA-derived peptides may be involved in host defense mechanisms. Copyright (C) 2000 Federation of European Biochemical Societies.

AB - Serum amyloid A (SAA) is a major acute-phase protein whose biochemical functions remain largely obscure. Human rheumatic synovial fluids were screened by high performance liquid chromatography mass spectrometry for SAA-derived peptides, specifically the sequence AGLPEKY (SAA98-104) which was previously shown to modulate various leukocyte functions. Two such fluids were found to contain a truncated version of SAA98-104. Synthetic SAA98-104 and several of its analogs were shown capable of binding isolated human CD4+ T-lymphocytes and stimulating them to produce interferon-γ. Given the high acute-phase serum level of SAA and its massive proteolysis by inflammatory related enzymes, SAA-derived peptides may be involved in host defense mechanisms. Copyright (C) 2000 Federation of European Biochemical Societies.

KW - Inflammation

KW - Interferon-γ

KW - Serum amyloid A

KW - T-lymphocyte

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Serum amyloid A-derived peptides, present in human rheumatic synovial fluids, induce the secretion of interferon-γ by human CD₄⁺ T-lymphocytes

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