Serotonin uptake to lymphocytes of patients with social phobia compared to normal individuals

Tal Barkan, Haggai Hermesh, Sofi Marom, David Gurwitz, Abraham Weizman, Moshe Rehavi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Several trials have indicated that selective serotonin reuptake inhibitors (SSRIs) are most efficient in the treatment of social phobia (SP). The activity of the serotonin transporter (5-HTT), as determined by [3H]5-HT uptake to blood lymphocytes, was measured in 15 drug-free patients with generalized SP (7M/8F, aged 21-37 years) and compared to 18 healthy control subjects (10M/8F, aged 21-32 years). The maximum uptake velocity (V max) of [3H]5-HT to fresh lymphocytes and the affinity (Km) of the 5-HTT were similar in the two groups (295 ± 155 versus 227 ± 117 pmol/min/mg protein and 767 ± 425 versus 709 ± 408 nM, respectively). This study suggests that the functioning of lymphocyte 5-HTT is unaltered in SP.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalEuropean Neuropsychopharmacology
Volume16
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • Lymphocytes
  • Serotonin
  • Serotonin transporter
  • Social phobia

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