TY - JOUR
T1 - Serotonin uptake to lymphocytes of patients with social phobia compared to normal individuals
AU - Barkan, Tal
AU - Hermesh, Haggai
AU - Marom, Sofi
AU - Gurwitz, David
AU - Weizman, Abraham
AU - Rehavi, Moshe
N1 - Funding Information:
R.W. and E.W.M. acknowledge generous support from the Binational Science Foundation (2016060) and from the Rosalinde and Arthur Gilbert Foundation. R.W. acknowledges support from the European Research Council (GAtransport). A.H.W. acknowledges support from the National Science Foundation (CHE-1464956). D.F.M. acknowledges support from the Israel Science Foundation (1310/15). P.L. was supported by an A*STAR graduate fellowship, and M.X.N. was supported in part by the NIH (T32GM066698). D.K. was supported in part by the Planning and Budgeting Committee (PBC) of the Israeli Council for Higher Education.
PY - 2006/1
Y1 - 2006/1
N2 - Several trials have indicated that selective serotonin reuptake inhibitors (SSRIs) are most efficient in the treatment of social phobia (SP). The activity of the serotonin transporter (5-HTT), as determined by [3H]5-HT uptake to blood lymphocytes, was measured in 15 drug-free patients with generalized SP (7M/8F, aged 21-37 years) and compared to 18 healthy control subjects (10M/8F, aged 21-32 years). The maximum uptake velocity (V max) of [3H]5-HT to fresh lymphocytes and the affinity (Km) of the 5-HTT were similar in the two groups (295 ± 155 versus 227 ± 117 pmol/min/mg protein and 767 ± 425 versus 709 ± 408 nM, respectively). This study suggests that the functioning of lymphocyte 5-HTT is unaltered in SP.
AB - Several trials have indicated that selective serotonin reuptake inhibitors (SSRIs) are most efficient in the treatment of social phobia (SP). The activity of the serotonin transporter (5-HTT), as determined by [3H]5-HT uptake to blood lymphocytes, was measured in 15 drug-free patients with generalized SP (7M/8F, aged 21-37 years) and compared to 18 healthy control subjects (10M/8F, aged 21-32 years). The maximum uptake velocity (V max) of [3H]5-HT to fresh lymphocytes and the affinity (Km) of the 5-HTT were similar in the two groups (295 ± 155 versus 227 ± 117 pmol/min/mg protein and 767 ± 425 versus 709 ± 408 nM, respectively). This study suggests that the functioning of lymphocyte 5-HTT is unaltered in SP.
KW - Lymphocytes
KW - Serotonin
KW - Serotonin transporter
KW - Social phobia
UR - http://www.scopus.com/inward/record.url?scp=29344434944&partnerID=8YFLogxK
U2 - 10.1016/j.euroneuro.2005.06.002
DO - 10.1016/j.euroneuro.2005.06.002
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C2 - 16023834
AN - SCOPUS:29344434944
SN - 0924-977X
VL - 16
SP - 19
EP - 23
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 1
ER -