Support for the serotonin-1D (5-HT1D) hypothesis of obsessive-compulsive disorder (OCD) and related conditions comes from a variety of sources. Some pharmacologic challenges with the 5-HT1D agonist sumatriptan, and case reports in which prolonged administration of 5-HT 1D agonists was associated with a therapeutic effect, suggest that 5-HT1D may play a role in obsessive-compulsive symptoms. Genetic studies have also found that polymorphism of the 5-HT1D gene may be preferentially transmitted to those patients with OCD. However, taking into account that OCD is a heterogeneous syndrome, the 5-HT1D hypothesis requires further investigation in order to disentangle the role of the 5-HT 1D receptor in this common and often severe disorder.
|Number of pages||4|
|Journal||Journal of Clinical Psychiatry|
|Issue number||SUPPL. 14|
|State||Published - 2004|