TY - JOUR
T1 - Seroprevalence of herpes simplex virus 1 and 2 and correlates of infection in Israel
AU - Davidovici, Batya B.
AU - Green, Manfred
AU - Marouni, Mehran J.
AU - Bassal, Ravit
AU - Pimenta, Jeanne M.
AU - Cohen, Dani
PY - 2006/5
Y1 - 2006/5
N2 - Background: The prevalence of infections with herpes viruses 1 and 2 (HSV1 and HSV2) have significantly changed in the developed countries during the last three decades. This study provides up-to-date estimates of HSV-1 and HSV-2 seroprevalence and information on the correlates of infection in a representative sample of the Israeli population. Methods: Three thousand eight hundred and eighty-one sera collected in 2000-2001 from an age-stratified general population sample were tested using an indirect IgG ELISA for type-specific HSV-1 and HSV-2 antibodies. Results: Unadjusted HSV-1 seroprevalence was 59.8% (95% confidence interval: 58.2-61.4) and increased with age in both genders. Multivariate analysis revealed that HSV-1 seroprevalence rates were significantly higher in females, non-Jews, subjects who were not born in Israel, inhabitants of Jerusalem and Southern Israel and among subjects also seropositive for HSV-2. Unadjusted HSV-2 seroprevalence among adults was 9.2% (95% confidence interval: 7.9-10.2), and was higher in females, peaking at 20.5% in females aged 40-49. In a multivariate model, females, subjects who were not born in Israel and residents of Jerusalem and Southern Israel were significantly associated with HSV-2 seropositivity. Conclusions: HSV-1 seroepidemiology in Israel resembles the trends in industrialized countries. HSV-2 seroprevalence rates is in the lower range reported across Europe.
AB - Background: The prevalence of infections with herpes viruses 1 and 2 (HSV1 and HSV2) have significantly changed in the developed countries during the last three decades. This study provides up-to-date estimates of HSV-1 and HSV-2 seroprevalence and information on the correlates of infection in a representative sample of the Israeli population. Methods: Three thousand eight hundred and eighty-one sera collected in 2000-2001 from an age-stratified general population sample were tested using an indirect IgG ELISA for type-specific HSV-1 and HSV-2 antibodies. Results: Unadjusted HSV-1 seroprevalence was 59.8% (95% confidence interval: 58.2-61.4) and increased with age in both genders. Multivariate analysis revealed that HSV-1 seroprevalence rates were significantly higher in females, non-Jews, subjects who were not born in Israel, inhabitants of Jerusalem and Southern Israel and among subjects also seropositive for HSV-2. Unadjusted HSV-2 seroprevalence among adults was 9.2% (95% confidence interval: 7.9-10.2), and was higher in females, peaking at 20.5% in females aged 40-49. In a multivariate model, females, subjects who were not born in Israel and residents of Jerusalem and Southern Israel were significantly associated with HSV-2 seropositivity. Conclusions: HSV-1 seroepidemiology in Israel resembles the trends in industrialized countries. HSV-2 seroprevalence rates is in the lower range reported across Europe.
KW - Herpes simplex virus types-1 and -2
KW - Israel
KW - Risk factors
KW - Seroprevalence
UR - http://www.scopus.com/inward/record.url?scp=33645949770&partnerID=8YFLogxK
U2 - 10.1016/j.jinf.2005.08.005
DO - 10.1016/j.jinf.2005.08.005
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C2 - 16213591
AN - SCOPUS:33645949770
SN - 0163-4453
VL - 52
SP - 367
EP - 373
JO - Journal of Infection
JF - Journal of Infection
IS - 5
ER -