Seronegative Lyme Disease

David A. Relman; Gideon Nesher; Thomas G. Osborn; Terry L. Moore; Felix Mor; Leonard Leibovici; Raymond J. Dattwyler; David J. Volkman; Benjamin J. Luft; John J. Halperin; Josephine Thomas; Marc G. Golightly

doi:10.1056/NEJM198905113201913

Seronegative Lyme Disease

David A. Relman, Gideon Nesher, Thomas G. Osborn, Terry L. Moore, Felix Mor, Leonard Leibovici, Raymond J. Dattwyler, David J. Volkman, Benjamin J. Luft, John J. Halperin, Josephine Thomas, Marc G. Golightly

Research output: Contribution to journal › Letter › peer-review

Abstract

To the Editor: Dattwyler and his associates (Dec. 1 issue)¹ make important and provocative observations about a group of patients with a clinical diagnosis of chronic Lyme disease who have no apparent serologic response to the causative agent, Borrelia burgdorferi. The specific T-cell proliferative response in these patients was similar to that found in a group of seropositive patients with chronic Lyme disease, suggesting that in some persons with this clinical syndrome, the T-cell and B-cell responses to B. burgdorferi are vastly unequal. One point needs clarification: although the serologic status of the patients seems to have been known…

Original language	English
Pages (from-to)	1279-1280
Number of pages	2
Journal	New England Journal of Medicine
Volume	320
Issue number	19
DOIs	https://doi.org/10.1056/NEJM198905113201913
State	Published - 11 May 1989
Externally published	Yes

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title = "Seronegative Lyme Disease",

abstract = "To the Editor: Dattwyler and his associates (Dec. 1 issue)1 make important and provocative observations about a group of patients with a clinical diagnosis of chronic Lyme disease who have no apparent serologic response to the causative agent, Borrelia burgdorferi. The specific T-cell proliferative response in these patients was similar to that found in a group of seropositive patients with chronic Lyme disease, suggesting that in some persons with this clinical syndrome, the T-cell and B-cell responses to B. burgdorferi are vastly unequal. One point needs clarification: although the serologic status of the patients seems to have been known…",

author = "Relman, {David A.} and Gideon Nesher and Osborn, {Thomas G.} and Moore, {Terry L.} and Felix Mor and Leonard Leibovici and Dattwyler, {Raymond J.} and Volkman, {David J.} and Luft, {Benjamin J.} and Halperin, {John J.} and Josephine Thomas and Golightly, {Marc G.}",

year = "1989",

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doi = "10.1056/NEJM198905113201913",

language = "אנגלית",

volume = "320",

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TY - JOUR

T1 - Seronegative Lyme Disease

AU - Relman, David A.

AU - Nesher, Gideon

AU - Osborn, Thomas G.

AU - Moore, Terry L.

AU - Mor, Felix

AU - Leibovici, Leonard

AU - Dattwyler, Raymond J.

AU - Volkman, David J.

AU - Luft, Benjamin J.

AU - Halperin, John J.

AU - Thomas, Josephine

AU - Golightly, Marc G.

PY - 1989/5/11

Y1 - 1989/5/11

N2 - To the Editor: Dattwyler and his associates (Dec. 1 issue)1 make important and provocative observations about a group of patients with a clinical diagnosis of chronic Lyme disease who have no apparent serologic response to the causative agent, Borrelia burgdorferi. The specific T-cell proliferative response in these patients was similar to that found in a group of seropositive patients with chronic Lyme disease, suggesting that in some persons with this clinical syndrome, the T-cell and B-cell responses to B. burgdorferi are vastly unequal. One point needs clarification: although the serologic status of the patients seems to have been known…

AB - To the Editor: Dattwyler and his associates (Dec. 1 issue)1 make important and provocative observations about a group of patients with a clinical diagnosis of chronic Lyme disease who have no apparent serologic response to the causative agent, Borrelia burgdorferi. The specific T-cell proliferative response in these patients was similar to that found in a group of seropositive patients with chronic Lyme disease, suggesting that in some persons with this clinical syndrome, the T-cell and B-cell responses to B. burgdorferi are vastly unequal. One point needs clarification: although the serologic status of the patients seems to have been known…

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Seronegative Lyme Disease

Abstract

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