Seronegative Lyme Disease

David A. Relman, Gideon Nesher, Thomas G. Osborn, Terry L. Moore, Felix Mor, Leonard Leibovici, Raymond J. Dattwyler, David J. Volkman, Benjamin J. Luft, John J. Halperin, Josephine Thomas, Marc G. Golightly

Research output: Contribution to journalLetterpeer-review

4 Scopus citations


To the Editor: Dattwyler and his associates (Dec. 1 issue)1 make important and provocative observations about a group of patients with a clinical diagnosis of chronic Lyme disease who have no apparent serologic response to the causative agent, Borrelia burgdorferi. The specific T-cell proliferative response in these patients was similar to that found in a group of seropositive patients with chronic Lyme disease, suggesting that in some persons with this clinical syndrome, the T-cell and B-cell responses to B. burgdorferi are vastly unequal. One point needs clarification: although the serologic status of the patients seems to have been known…

Original languageEnglish
Pages (from-to)1279-1280
Number of pages2
JournalNew England Journal of Medicine
Issue number19
StatePublished - 11 May 1989
Externally publishedYes


Dive into the research topics of 'Seronegative Lyme Disease'. Together they form a unique fingerprint.

Cite this