TY - JOUR
T1 - Serology in the 21st century
T2 - The molecular-level analysis of the serum antibody repertoire
AU - Wine, Yariv
AU - Horton, Andrew P.
AU - Ippolito, Gregory C.
AU - Georgiou, George
N1 - Publisher Copyright:
© 2015.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - The ensemble of antibodies found in serum and secretions represents the key adaptive component of B-cell mediated humoral immunity. The antibody repertoire is shaped by the historical record of exposure to exogenous factors such as pathogens and vaccines, as well as by endogenous host-intrinsic factors such as genetics, self-antigens, and age. Thanks to very recent technology advancements it is now becoming possible to identify and quantify the individual antibodies comprising the serological repertoire. In parallel, the advent of high throughput methods for antigen and immunosignature discovery opens up unprecedented opportunities to transform our understanding of numerous key questions in adaptive humoral immunity, including the nature and dynamics of serological memory, the role of polyspecific antibodies in health and disease and how protective responses to infections or vaccine challenge arise. Additionally, these technologies also hold great promise for therapeutic antibody and biomarker discovery in a variety of settings.
AB - The ensemble of antibodies found in serum and secretions represents the key adaptive component of B-cell mediated humoral immunity. The antibody repertoire is shaped by the historical record of exposure to exogenous factors such as pathogens and vaccines, as well as by endogenous host-intrinsic factors such as genetics, self-antigens, and age. Thanks to very recent technology advancements it is now becoming possible to identify and quantify the individual antibodies comprising the serological repertoire. In parallel, the advent of high throughput methods for antigen and immunosignature discovery opens up unprecedented opportunities to transform our understanding of numerous key questions in adaptive humoral immunity, including the nature and dynamics of serological memory, the role of polyspecific antibodies in health and disease and how protective responses to infections or vaccine challenge arise. Additionally, these technologies also hold great promise for therapeutic antibody and biomarker discovery in a variety of settings.
UR - http://www.scopus.com/inward/record.url?scp=84936880720&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2015.06.009
DO - 10.1016/j.coi.2015.06.009
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AN - SCOPUS:84936880720
SN - 0952-7915
VL - 35
SP - 89
EP - 97
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
ER -
