Sequential levels of ceftriaxone in intervertebral disc removed as part of scoliosis surgery

R. Lang*, Y. Folman, M. Ravid, T. Bental, R. Gepstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A single intravenous loading dose of 1 g ceftriaxone was injected at different intervals before surgery for correction of spinal scoliosis. Serum and concomitant disc samples were obtained and assay was performed using high-pressure liquid chromatography. Data showed that the antibiotic levels in intervertebral disc space reached 3.5 mcg/mg, which is above the minimum inhibitory concentration for most of the relevant pathogens, as early as 1 hour after intravenous administration. These therapeutic levels were maintained for more than 5 hours, an accepted period for most spinal surgical procedures.

Original languageEnglish
Pages (from-to)209-211
Number of pages3
JournalClinical Orthopaedics and Related Research
Volume315
DOIs
StatePublished - 1995
Externally publishedYes

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