TY - JOUR
T1 - Sequential levels of ceftriaxone in intervertebral disc removed as part of scoliosis surgery
AU - Lang, R.
AU - Folman, Y.
AU - Ravid, M.
AU - Bental, T.
AU - Gepstein, R.
PY - 1995
Y1 - 1995
N2 - A single intravenous loading dose of 1 g ceftriaxone was injected at different intervals before surgery for correction of spinal scoliosis. Serum and concomitant disc samples were obtained and assay was performed using high-pressure liquid chromatography. Data showed that the antibiotic levels in intervertebral disc space reached 3.5 mcg/mg, which is above the minimum inhibitory concentration for most of the relevant pathogens, as early as 1 hour after intravenous administration. These therapeutic levels were maintained for more than 5 hours, an accepted period for most spinal surgical procedures.
AB - A single intravenous loading dose of 1 g ceftriaxone was injected at different intervals before surgery for correction of spinal scoliosis. Serum and concomitant disc samples were obtained and assay was performed using high-pressure liquid chromatography. Data showed that the antibiotic levels in intervertebral disc space reached 3.5 mcg/mg, which is above the minimum inhibitory concentration for most of the relevant pathogens, as early as 1 hour after intravenous administration. These therapeutic levels were maintained for more than 5 hours, an accepted period for most spinal surgical procedures.
UR - http://www.scopus.com/inward/record.url?scp=0029066973&partnerID=8YFLogxK
U2 - 10.1097/00003086-199506000-00022
DO - 10.1097/00003086-199506000-00022
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AN - SCOPUS:0029066973
SN - 0009-921X
VL - 315
SP - 209
EP - 211
JO - Clinical Orthopaedics and Related Research
JF - Clinical Orthopaedics and Related Research
ER -