Sequential folding of a messenger RNA molecule

Ruth Nussinov; Ignacio Tinoco

doi:10.1016/0022-2836(81)90008-5

Sequential folding of a messenger RNA molecule

Ruth Nussinov^*, Ignacio Tinoco

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The existence of a new, efficient algorithm for secondary structure prediction enables us to study the folding pattern of a messenger RNA chain. Our results indicate that successively longer RNA sequences with the same 5′-ends fold sequentially, usually keeping the stable close-range hairpin loops and rearranging the long-range stems. This path will shorten the time the messenger RNA molecule needs in order to attain its preferred structure. It can also align splicing sites in a favorable orientation before the whole molecule is synthesized. Our studies were carried out on the simian virus 40 late precursor and processed mRNA.

Original language	English
Pages (from-to)	519-533
Number of pages	15
Journal	Journal of Molecular Biology
Volume	151
Issue number	3
DOIs	https://doi.org/10.1016/0022-2836(81)90008-5
State	Published - 25 Sep 1981
Externally published	Yes

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title = "Sequential folding of a messenger RNA molecule",

abstract = "The existence of a new, efficient algorithm for secondary structure prediction enables us to study the folding pattern of a messenger RNA chain. Our results indicate that successively longer RNA sequences with the same 5′-ends fold sequentially, usually keeping the stable close-range hairpin loops and rearranging the long-range stems. This path will shorten the time the messenger RNA molecule needs in order to attain its preferred structure. It can also align splicing sites in a favorable orientation before the whole molecule is synthesized. Our studies were carried out on the simian virus 40 late precursor and processed mRNA.",

author = "Ruth Nussinov and Ignacio Tinoco",

note = "Funding Information: We thank A. B. <Jacobson,w ith whom the program was developed, for her interest, and discussions, and D. Canaani and G. Pieczenik for discussions and suggestions. We also thank K. Wiley and S. Wong from the Laboratory of Chemical Biodynamics computer center. This work was supported in part by National Institutes of Health grant GM10840 and by the Assistant Secretary for Environment, Office of Health and Environmental Research. Biomedical and Environmental Research Division of the U.S. Department of Energy under contract no. W-7405.ENG-48.",

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Sequential folding of a messenger RNA molecule

Abstract

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