Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways

J. Yanai*, Y. Rogel-Fuchs, C. G. Pick, T. Slotkin, F. J. Seidler, E. A. Zahalka, M. E. Newman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Mice were injected bilaterally into the septum with 6-hydroxydopamine and 6 weeks later the hippocampi were assayed for activity of choline acetyltransferase, muscarinic receptor binding capabilities and for formation of inositol phosphate in response to direct (carbachol) or presynaptically elicited (K+) stimulation of the postsynaptic receptors. Levels of dopamine in the septum were reduced by 70% in the lesioned animals and hippocampal choline acetyltranferase was elevated by the same amount. The Bmax of muscarinic binding was significantly reduced without changes in Kd; nevertheless, carbachol-induced stimulation of formation of inositol phosphate was unaffected. The response of K+ was markedly elevated in the 6-hydroxydopamine-treated animals. Thus, the regulatory effect of A10-septal dopaminergic pathways on the septohippocampal cholinergic innervations is both on the presynaptic and postsynaptic levels.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalNeuropharmacology
Volume32
Issue number2
DOIs
StatePublished - Feb 1993
Externally publishedYes

Keywords

  • 6-hydroxydopamine
  • A10-septal pathways
  • choline acetyltransferase
  • hippocampus
  • inositol phosphate formation
  • muscarinic receptors
  • septum

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