@article{0ddd9f46c8d54c67887464f964f7af6f,
title = "Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways",
abstract = "Mice were injected bilaterally into the septum with 6-hydroxydopamine and 6 weeks later the hippocampi were assayed for activity of choline acetyltransferase, muscarinic receptor binding capabilities and for formation of inositol phosphate in response to direct (carbachol) or presynaptically elicited (K+) stimulation of the postsynaptic receptors. Levels of dopamine in the septum were reduced by 70% in the lesioned animals and hippocampal choline acetyltranferase was elevated by the same amount. The Bmax of muscarinic binding was significantly reduced without changes in Kd; nevertheless, carbachol-induced stimulation of formation of inositol phosphate was unaffected. The response of K+ was markedly elevated in the 6-hydroxydopamine-treated animals. Thus, the regulatory effect of A10-septal dopaminergic pathways on the septohippocampal cholinergic innervations is both on the presynaptic and postsynaptic levels.",
keywords = "6-hydroxydopamine, A10-septal pathways, choline acetyltransferase, hippocampus, inositol phosphate formation, muscarinic receptors, septum",
author = "J. Yanai and Y. Rogel-Fuchs and Pick, {C. G.} and T. Slotkin and Seidler, {F. J.} and Zahalka, {E. A.} and Newman, {M. E.}",
year = "1993",
month = feb,
doi = "10.1016/0028-3908(93)90090-P",
language = "אנגלית",
volume = "32",
pages = "113--117",
journal = "Neuropharmacology",
issn = "0028-3908",
publisher = "Elsevier Ltd.",
number = "2",
}