SEPT9_V1 protein expression is associated with human cancer cell resistance to microtubule disrupting agents

Sharon Amir; Nicola J. Mabjeesh

doi:10.4161/cbt.6.12.4971

SEPT9_V1 protein expression is associated with human cancer cell resistance to microtubule disrupting agents

Research output: Contribution to journal › Article › peer-review

Abstract

SEPT9 is a mammalian septin family member. There is growing evidence that SEPT9 plays a role in cancer. The protein product, SEPT9_V1, associates with microtubules and interacts with hypoxia-inducible factor (HIF)-1α, the regulated subunit of the key transcription factor HIF-1. HIF-1 transcriptional activity is thoroughly dependent on intact microtubules. We tested the hypothesis that SEPT9_V1 confers resistance to microtubule-mediated HIF-1 inhibitors. SEPT9_V1 protein expression was strongly correlated with susceptibility of a wide range of cancer cells to 2-methoxyestradiol and paclitaxel. Our results revealed that SEPT9_V1 could serve as a biomarker for therapeutic resistance to microtubule disrupting agents.

Original language	English
Pages (from-to)	1926-1931
Number of pages	6
Journal	Cancer Biology and Therapy
Volume	6
Issue number	12
DOIs	https://doi.org/10.4161/cbt.6.12.4971
State	Published - Dec 2007
Externally published	Yes

Keywords

2-methoxyestradiol
Cancer
HIF
Microtubules
Paclitaxel
SEPT9
Septins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/cbt.6.12.4971

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title = "SEPT9_V1 protein expression is associated with human cancer cell resistance to microtubule disrupting agents",

abstract = "SEPT9 is a mammalian septin family member. There is growing evidence that SEPT9 plays a role in cancer. The protein product, SEPT9_V1, associates with microtubules and interacts with hypoxia-inducible factor (HIF)-1α, the regulated subunit of the key transcription factor HIF-1. HIF-1 transcriptional activity is thoroughly dependent on intact microtubules. We tested the hypothesis that SEPT9_V1 confers resistance to microtubule-mediated HIF-1 inhibitors. SEPT9_V1 protein expression was strongly correlated with susceptibility of a wide range of cancer cells to 2-methoxyestradiol and paclitaxel. Our results revealed that SEPT9_V1 could serve as a biomarker for therapeutic resistance to microtubule disrupting agents.",

keywords = "2-methoxyestradiol, Cancer, HIF, Microtubules, Paclitaxel, SEPT9, Septins",

author = "Sharon Amir and Mabjeesh, {Nicola J.}",

note = "Funding Information: We thank Esther Eshkol for editorial assistance. This work was supported by the M.K. Humanitarian Foundation, PCF Israel, Bat Sheva De Rothschild Foundation Grant of the Israel Ministry of Health and the Israel Academy of Science in memory of the late Professors A. Eldor and Y. Matzner.",

year = "2007",

month = dec,

doi = "10.4161/cbt.6.12.4971",

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AU - Amir, Sharon

AU - Mabjeesh, Nicola J.

N1 - Funding Information: We thank Esther Eshkol for editorial assistance. This work was supported by the M.K. Humanitarian Foundation, PCF Israel, Bat Sheva De Rothschild Foundation Grant of the Israel Ministry of Health and the Israel Academy of Science in memory of the late Professors A. Eldor and Y. Matzner.

PY - 2007/12

Y1 - 2007/12

N2 - SEPT9 is a mammalian septin family member. There is growing evidence that SEPT9 plays a role in cancer. The protein product, SEPT9_V1, associates with microtubules and interacts with hypoxia-inducible factor (HIF)-1α, the regulated subunit of the key transcription factor HIF-1. HIF-1 transcriptional activity is thoroughly dependent on intact microtubules. We tested the hypothesis that SEPT9_V1 confers resistance to microtubule-mediated HIF-1 inhibitors. SEPT9_V1 protein expression was strongly correlated with susceptibility of a wide range of cancer cells to 2-methoxyestradiol and paclitaxel. Our results revealed that SEPT9_V1 could serve as a biomarker for therapeutic resistance to microtubule disrupting agents.

AB - SEPT9 is a mammalian septin family member. There is growing evidence that SEPT9 plays a role in cancer. The protein product, SEPT9_V1, associates with microtubules and interacts with hypoxia-inducible factor (HIF)-1α, the regulated subunit of the key transcription factor HIF-1. HIF-1 transcriptional activity is thoroughly dependent on intact microtubules. We tested the hypothesis that SEPT9_V1 confers resistance to microtubule-mediated HIF-1 inhibitors. SEPT9_V1 protein expression was strongly correlated with susceptibility of a wide range of cancer cells to 2-methoxyestradiol and paclitaxel. Our results revealed that SEPT9_V1 could serve as a biomarker for therapeutic resistance to microtubule disrupting agents.

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KW - Cancer

KW - HIF

KW - Microtubules

KW - Paclitaxel

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SEPT9_V1 protein expression is associated with human cancer cell resistance to microtubule disrupting agents

Abstract

Keywords

UN SDGs

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