@article{4540ba4def4143e5aa39606da4808e12,
title = "SEPT9\_V1 protein expression is associated with human cancer cell resistance to microtubule disrupting agents",
abstract = "SEPT9 is a mammalian septin family member. There is growing evidence that SEPT9 plays a role in cancer. The protein product, SEPT9\_V1, associates with microtubules and interacts with hypoxia-inducible factor (HIF)-1α, the regulated subunit of the key transcription factor HIF-1. HIF-1 transcriptional activity is thoroughly dependent on intact microtubules. We tested the hypothesis that SEPT9\_V1 confers resistance to microtubule-mediated HIF-1 inhibitors. SEPT9\_V1 protein expression was strongly correlated with susceptibility of a wide range of cancer cells to 2-methoxyestradiol and paclitaxel. Our results revealed that SEPT9\_V1 could serve as a biomarker for therapeutic resistance to microtubule disrupting agents.",
keywords = "2-methoxyestradiol, Cancer, HIF, Microtubules, Paclitaxel, SEPT9, Septins",
author = "Sharon Amir and Mabjeesh, \{Nicola J.\}",
note = "Funding Information: We thank Esther Eshkol for editorial assistance. This work was supported by the M.K. Humanitarian Foundation, PCF Israel, Bat Sheva De Rothschild Foundation Grant of the Israel Ministry of Health and the Israel Academy of Science in memory of the late Professors A. Eldor and Y. Matzner.",
year = "2007",
month = dec,
doi = "10.4161/cbt.6.12.4971",
language = "אנגלית",
volume = "6",
pages = "1926--1931",
journal = "Cancer Biology and Therapy",
issn = "1538-4047",
publisher = "Taylor and Francis Ltd.",
number = "12",
}
