@article{c453fb5285214a47b882ea3a9ea00eb3,
title = "Sepsis Related Mortality Associated with an Inflammatory Burst in Patients Admitting to the Department of Internal Medicine with Apparently Normal C-Reactive Protein Concentration",
abstract = "Background: Patients who are admitted to the Department of Internal Medicine with apparently normal C-reactive protein (CRP) concentration impose a special challenge due the as-sumption that they might not harbor a severe and potentially lethal medical condition. Methods: A retrospective cohort of all patients who were admitted to the Department of Internal Medicine with a CRP concentration of ≤31.9 mg/L and had a second CRP test obtained within the next 24 h. Seven day mortality data were analyzed. Results: Overall, 3504 patients were analyzed with a mean first and second CRP of 8.8 (8.5) and 14.6 (21.6) mg/L, respectively. The seven day mortality increased from 1.8% in the first quartile of the first CRP to 7.5% in the fourth quartile of the first CRP (p < 0.0001) and from 0.6% in the first quartile of the second CRP to 9.5% in the fourth quartile of the second CRP test (p < 0.0001), suggesting a clear relation between the admission CRP and in hospital seven day mortality. Conclusions: An association exists between the quartiles of CRP and 7-day mortality as well as sepsis related cause of death. Furthermore, the CRP values 24 h after hospital admission improved the discrimination.",
keywords = "C-reactive protein, inflammation, mortality causes",
author = "Ronnie Meilik and Hadas Ben-Assayag and Ahuva Meilik and Shlomo Berliner and David Zeltser and Itzhak Shapira and Ori Rogowski and Ilana Goldiner and Shani Shenhar-Tsarfaty and Asaf Wasserman",
note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
month = jun,
day = "1",
doi = "10.3390/jcm11113151",
language = "אנגלית",
volume = "11",
journal = "Journal of Clinical Medicine",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "11",
}