Separating wheat from chaff: Joining biomedical knowledge and patient data for repurposing medications

Galia Nordon, Gideon Koren, Varda Shalev, Eric Horvitz, Kira Radinsky

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We present a system that jointly harnesses large-scale electronic health records data and a concept graph mined from the medical literature to guide drug repurposing-the process of applying known drugs in new ways to treat diseases. Our study is unique in methods and scope, per the scale of the concept graph and the quantity of data. We harness 10 years of nation-wide medical records of more than 1.5 million people and extract medical knowledge from all of PubMed, the world's largest corpus of online biomedical literature. We employ links on the concept graph to provide causal signals to prioritize candidate influences between medications and target diseases. We show results of the system on studies of drug repurposing for hypertension and diabetes. In both cases, we present drug families identified by the algorithm which were previously unknown. We verify the results via clinical expert opinion and by prospective clinical trials on hypertension.

Original languageEnglish
Title of host publication33rd AAAI Conference on Artificial Intelligence, AAAI 2019, 31st Innovative Applications of Artificial Intelligence Conference, IAAI 2019 and the 9th AAAI Symposium on Educational Advances in Artificial Intelligence, EAAI 2019
PublisherAAAI press
Pages9565-9572
Number of pages8
ISBN (Electronic)9781577358091
StatePublished - 2019
Externally publishedYes
Event33rd AAAI Conference on Artificial Intelligence, AAAI 2019, 31st Annual Conference on Innovative Applications of Artificial Intelligence, IAAI 2019 and the 9th AAAI Symposium on Educational Advances in Artificial Intelligence, EAAI 2019 - Honolulu, United States
Duration: 27 Jan 20191 Feb 2019

Publication series

Name33rd AAAI Conference on Artificial Intelligence, AAAI 2019, 31st Innovative Applications of Artificial Intelligence Conference, IAAI 2019 and the 9th AAAI Symposium on Educational Advances in Artificial Intelligence, EAAI 2019

Conference

Conference33rd AAAI Conference on Artificial Intelligence, AAAI 2019, 31st Annual Conference on Innovative Applications of Artificial Intelligence, IAAI 2019 and the 9th AAAI Symposium on Educational Advances in Artificial Intelligence, EAAI 2019
Country/TerritoryUnited States
CityHonolulu
Period27/01/191/02/19

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