TY - JOUR
T1 - Sentinel-node guided lymph-node dissection for Merkel cell carcinoma
AU - Wasserberg, N.
AU - Feinmesser, M.
AU - Schachter, J.
AU - Fenig, E.
AU - Gutman, H.
PY - 1999/8
Y1 - 1999/8
N2 - Merkel cell carcinoma is an aggressive neuroendocrine skin tumour. Treatment is still debatable. Merkel cell carcinoma resembles malignant melanoma in its cutaneous presentation and its embryonic origin; both have unpredictable biological behaviour, early regional lymph node involvement, early distant metastases and a high recurrence rate. In light of these common features, we used pre-operative lymphoscintigraphy, intraoperative lymph-node mapping and sentinel-node biopsy - a well-described technique for the treatment of melanoma - in a 60-year-old man with Merkel cell carcinoma in the right buttock. Following frozen section identification of a metastatic first-order sentinel node, radical right groin dissection was performed. All the other lymph nodes in this basin proved to be disease-free, including the second-order sentinel node and Cloquet node. The patient is now being treated with adjuvant chemotherapy and radiotherapy. This case shows that sentinel-node guided dissection is applicable to Merkel cell carcinoma.
AB - Merkel cell carcinoma is an aggressive neuroendocrine skin tumour. Treatment is still debatable. Merkel cell carcinoma resembles malignant melanoma in its cutaneous presentation and its embryonic origin; both have unpredictable biological behaviour, early regional lymph node involvement, early distant metastases and a high recurrence rate. In light of these common features, we used pre-operative lymphoscintigraphy, intraoperative lymph-node mapping and sentinel-node biopsy - a well-described technique for the treatment of melanoma - in a 60-year-old man with Merkel cell carcinoma in the right buttock. Following frozen section identification of a metastatic first-order sentinel node, radical right groin dissection was performed. All the other lymph nodes in this basin proved to be disease-free, including the second-order sentinel node and Cloquet node. The patient is now being treated with adjuvant chemotherapy and radiotherapy. This case shows that sentinel-node guided dissection is applicable to Merkel cell carcinoma.
KW - Lymph-node dissection
KW - Merkel cell carcinoma
KW - Neuroendocrine tumours
KW - Sentinel node
UR - http://www.scopus.com/inward/record.url?scp=0033180028&partnerID=8YFLogxK
U2 - 10.1053/ejso.1999.0675
DO - 10.1053/ejso.1999.0675
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C2 - 10419721
AN - SCOPUS:0033180028
SN - 0748-7983
VL - 25
SP - 444
EP - 446
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
IS - 4
ER -