@article{de506d44362e450eadb43aa8ced90aa3,
title = "Sentinel lymph node mapping using ICG fluorescence and cone beam CT - a feasibility study in a rabbit model of oral cancer",
abstract = "Background: Current sentinel lymph node biopsy (SLNB) techniques, including use of radioisotopes, have disadvantages including the use of a radioactive tracer. Indocyanine green (ICG) based near-infrared (NIR) fluorescence imaging and cone beam CT (CBCT) have advantages for intraoperative use. However, limited literature exists regarding their use in head and neck cancer SLNB. Methods: This was a prospective, non-randomized study using a rabbit oral cavity VX2 squamous cell carcinoma model (n = 10) which develops lymph node metastasis. Pre-operatively, images were acquired by MicroCT. During surgery, CBCT and NIR fluorescence imaging of ICG was used to map and guide the SLNB resection. Results: Intraoperative use of ICG to guide fluorescence resection resulted in identification of all lymph nodes identified by pre-operative CT. CBCT was useful for near real time intraoperative imaging and 3D reconstruction. Conclusions: This pre-clinical study further demonstrates the technical feasibility, limitations and advantages of intraoperative NIR-guided ICG imaging for SLN identification as a complementary method during head and neck surgery.",
keywords = "Cone beam CT, Head and neck cancer, Head and neck surgery, Indocyanine green, Near-infrared fluorescence imaging, Sentinel lymph node biopsy",
author = "Nidal Muhanna and Chan, {Harley H.L.} and Douglas, {Catriona M.} and Daly, {Michael J.} and Atul Jaidka and Donovan Eu and Jonathan Bernstein and Townson, {Jason L.} and Irish, {Jonathan C.}",
note = "Publisher Copyright: {\textcopyright} 2020 The Author(s).",
year = "2020",
month = sep,
day = "14",
doi = "10.1186/s12880-020-00507-x",
language = "אנגלית",
volume = "20",
journal = "BMC Medical Imaging",
issn = "1471-2342",
publisher = "BioMed Central Ltd.",
number = "1",
}
