TY - JOUR
T1 - Sensitized emission from a chemotherapeutic drug conjugated to CdSe/ZnS QDs
AU - Narayanan, S. Shankara
AU - Sinha, Sudarson Sekhar
AU - Pal, Samir Kumar
PY - 2008/8/21
Y1 - 2008/8/21
N2 - Picosecond-resolved photoluminescence (PL) and polarization gated PL anisotropy measurements have been performed to confirm a strong sensitized emission from a chemotherapeutic drug, Merocyanine 540 (MC540), conjugated to highly luminescent CdSe/ZnS quantum dots (QDs) via Förster resonance energy transfer (FRET) from QDs (donor) to the drug molecule (acceptor). Both steady-state and time-resolved PL measurements clearly confirm FRET to be the reason behind the PL quenching of the QDs (energy donor) in the QD-drug complex. The picosecond-resolved PL transients of QD-drug complex monitored at the donor (500 nm) and the acceptor peak emission (620 nm) wavelengths revealed a fast decay time for the donor (500 nm) and a rise component of similar time scale for the acceptor (620 nm). The observation of similar decay and rise times for the donor and the acceptor, respectively, in the QD-MC540 system gave a clear signature of the sensitized emission from MC540. Further confirmation of sensitization has been obtained from the picosecond-resolved anisotropy measurements, which revealed a fast component indicating efficient energy transfer from dipolar QD excitons to the conjugated drug molecules. It is anticipated that the present characterization of sensitized emission from a donor - acceptor pair formed by chemotherapeutic drugs and QDs can be applied to other systems as well for the confirmation of sensitized emission.
AB - Picosecond-resolved photoluminescence (PL) and polarization gated PL anisotropy measurements have been performed to confirm a strong sensitized emission from a chemotherapeutic drug, Merocyanine 540 (MC540), conjugated to highly luminescent CdSe/ZnS quantum dots (QDs) via Förster resonance energy transfer (FRET) from QDs (donor) to the drug molecule (acceptor). Both steady-state and time-resolved PL measurements clearly confirm FRET to be the reason behind the PL quenching of the QDs (energy donor) in the QD-drug complex. The picosecond-resolved PL transients of QD-drug complex monitored at the donor (500 nm) and the acceptor peak emission (620 nm) wavelengths revealed a fast decay time for the donor (500 nm) and a rise component of similar time scale for the acceptor (620 nm). The observation of similar decay and rise times for the donor and the acceptor, respectively, in the QD-MC540 system gave a clear signature of the sensitized emission from MC540. Further confirmation of sensitization has been obtained from the picosecond-resolved anisotropy measurements, which revealed a fast component indicating efficient energy transfer from dipolar QD excitons to the conjugated drug molecules. It is anticipated that the present characterization of sensitized emission from a donor - acceptor pair formed by chemotherapeutic drugs and QDs can be applied to other systems as well for the confirmation of sensitized emission.
UR - http://www.scopus.com/inward/record.url?scp=51049121934&partnerID=8YFLogxK
U2 - 10.1021/jp8032534
DO - 10.1021/jp8032534
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AN - SCOPUS:51049121934
SN - 1932-7447
VL - 112
SP - 12716
EP - 12720
JO - Journal of Physical Chemistry C
JF - Journal of Physical Chemistry C
IS - 33
ER -