Semi-stochastic cell-level computational modelling of cellular forces: application to contractures in burns and cyclic loading

F. J. Vermolen*, A. Gefen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A phenomenological model is formulated to model cellular forces on extracellular material. The model is capable of modelling both expansion and contractile forces. This work is based on the assumption of linear elasticity, which allows a superposition argument to arrive at fundamental expressions for cellular forces. It is also shown how the cellular forces can be implemented using different strategies, as well as an extension to cellular point sources. Illustrations are given for modelling a (permanent) contraction (e.g. a contracture) of burns and for cyclic loading by the cells.

Original languageEnglish
Pages (from-to)1181-1195
Number of pages15
JournalBiomechanics and Modeling in Mechanobiology
Volume14
Issue number6
DOIs
StatePublished - 1 Nov 2015

Funding

FundersFunder number
Nederlandse Brandwonden Stichting

    Keywords

    • Burns
    • Cell-level modeling
    • Cellular forces
    • Contractors
    • Semi-stochastic model

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