Self prion protein peptides are immunogenic in lewis rats

Lina Souan, Raanan Margalit, Ori Brenner, Irun R. Cohen, Felix Mor

Research output: Contribution to journalArticlepeer-review

Abstract

Prion diseases are caused by abnormal folding of the prion protein. The paradigm is that the prion protein is not immunogenic because the immune system must be tolerant to such a self protein. In an attempt to identify immunogenic prion peptides, we immunized Lewis rats with peptides that fitted the MHC class II RT1.B1 motif. Both humoral and cellular immunity to the prion peptides were obtained without any harmful effects to young animals. However, when 8-month-old rats were immunized, a sixth (6/36) of the rats developed severe skin inflammation with concomitant hair loss. These findings suggest that immunity to self-prion peptides can be readily induced in Lewis rats and that this immune response may have pathogenic consequences in older rats.

Original languageEnglish
Pages (from-to)303-310
Number of pages8
JournalJournal of Autoimmunity
Volume17
Issue number4
DOIs
StatePublished - 1 Dec 2001
Externally publishedYes

Keywords

  • MHC class II motif
  • Prion protein
  • T cell lines
  • Transmissible spongiform encephalopathies

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