Abstract
Self-immolative dendrimers were recently developed and introduced as a potential platform for a single-triggered multi-prodrug. These unique structural dendrimers can release all of their tail units through domino-like chain fragmentation, which is initiated by a single cleavage at the den-drimer core. The incorporation of drug molecules as the tail units and an enzyme substrate as the trigger generates a multi-prodrug unit that is activated with a single enzymatic cleavage. We have demonstrated several examples of self-immolative dendritic prodrug systems and have shown significant advantages with respect to the appropriate monomeric prodrug. We anticipate that single-triggered, dendritic prodrugs will be exploited to further improve selective chemotherapeutic approaches in cancer therapy.
Original language | English |
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Pages (from-to) | 1569-1578 |
Number of pages | 10 |
Journal | Journal of Polymer Science, Part A: Polymer Chemistry |
Volume | 44 |
Issue number | 5 |
DOIs | |
State | Published - 1 Mar 2006 |
Keywords
- Biological applications of polymers
- Cancer
- Dendrimers
- Drug delivery
- Prodrug
- Self-immolative
- Water-soluble polymers