Self-immolative dendrimers as novel drug delivery platforms

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Abstract

Self-immolative dendrimers were recently developed and introduced as a potential platform for a single-triggered multi-prodrug. These unique structural dendrimers can release all of their tail units through domino-like chain fragmentation, which is initiated by a single cleavage at the den-drimer core. The incorporation of drug molecules as the tail units and an enzyme substrate as the trigger generates a multi-prodrug unit that is activated with a single enzymatic cleavage. We have demonstrated several examples of self-immolative dendritic prodrug systems and have shown significant advantages with respect to the appropriate monomeric prodrug. We anticipate that single-triggered, dendritic prodrugs will be exploited to further improve selective chemotherapeutic approaches in cancer therapy.

Original languageEnglish
Pages (from-to)1569-1578
Number of pages10
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume44
Issue number5
DOIs
StatePublished - 1 Mar 2006

Keywords

  • Biological applications of polymers
  • Cancer
  • Dendrimers
  • Drug delivery
  • Prodrug
  • Self-immolative
  • Water-soluble polymers

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