Self-immolative dendrimers: A distinctive approach to molecular amplification

Michal Avital-Shmilovici, Doron Shabat

Research output: Contribution to journalArticlepeer-review


About six years ago, almost simultaneously, three independent groups reported the synthesis of a novel class of dendritic molecules. These molecules were equipped with a focal trigger; reaction at the trigger initiated the fragmentation of the dendrimer to its building blocks in a domino-like manner with consequent release of at least two tail-units. We termed these molecules "self-immolative dendrimers" and demonstrated their distinctive ability to achieve molecular amplification of the initial triggering signal. The unique amplification effect obtained by self-immolative dendrimers is useful in the fields of drug delivery systems and diagnostic applications. This highlight summarizes the design, function, and applications of this unique class of molecules.

Original languageEnglish
Pages (from-to)1073-1080
Number of pages8
JournalSoft Matter
Issue number6
StatePublished - 2010


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