Self-assembly of a tetrahedral lectin into predesigned diamondlike protein crystals

Nir Dotan, Dorit Arad, Felix Frolow, Amihay Freeman

Research output: Contribution to journalArticlepeer-review

Abstract

Binding sites analogous to those of sp3 carbon are presented by concanavalin A. This lectin has now been cross-linked with a bismannopyranoside which contains the C2 spacer required to form the computer-modeled diamondlike three-dimensional protein lattice shown in the picture.

Original languageEnglish
Pages (from-to)2363-2366
Number of pages4
JournalAngewandte Chemie - International Edition
Volume38
Issue number16
DOIs
StatePublished - 12 Aug 1999

Keywords

  • Crystal engineering
  • Lectins
  • Molecular modeling
  • Proteins
  • Supramolecular chemistry

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