Self-Assembled Peptide Nano-Superstructure towards Enzyme Mimicking Hydrolysis

Yu Chen, Yuqin Yang, Asuka A. Orr, Pandeeswar Makam, Boris Redko, Elvira Haimov, Yannan Wang, Linda J.W. Shimon, Sigal Rencus-Lazar, Meiting Ju, Phanourios Tamamis, Hao Dong, Ehud Gazit

Research output: Contribution to journalArticlepeer-review


The structural arrangement of amino acid residues in native enzymes underlies their remarkable catalytic properties, thus providing a notable point of reference for designing potent yet simple biomimetic catalysts. Herein, we describe a minimalistic approach to construct a dipeptide-based nano-superstructure with enzyme-like activity. The self-assembled biocatalyst comprises one peptide as a single building block, readily synthesized from histidine. Through coordination with zinc ion, the peptide self-assembly procedure allows the formation of supramolecular β-sheet ordered nanocrystals, which can be used as basic units to further construct higher-order superstructure. As a result, remarkable hydrolysis activity and enduring stability are demonstrated. Our work exemplifies the use of a bioinspired supramolecular assembly approach to develop next-generation biocatalysts for biotechnological applications.

Original languageEnglish
Pages (from-to)17164-17170
Number of pages7
JournalAngewandte Chemie - International Edition
Issue number31
StatePublished - 26 Jul 2021


  • biocatalysis
  • nano-superstructure
  • peptide
  • self-assembly
  • supramolecular chemistry


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