@article{ec4e1421f2504316a91c718948101f74,
title = "Self-Assembled Peptide Nano-Superstructure towards Enzyme Mimicking Hydrolysis",
abstract = "The structural arrangement of amino acid residues in native enzymes underlies their remarkable catalytic properties, thus providing a notable point of reference for designing potent yet simple biomimetic catalysts. Herein, we describe a minimalistic approach to construct a dipeptide-based nano-superstructure with enzyme-like activity. The self-assembled biocatalyst comprises one peptide as a single building block, readily synthesized from histidine. Through coordination with zinc ion, the peptide self-assembly procedure allows the formation of supramolecular β-sheet ordered nanocrystals, which can be used as basic units to further construct higher-order superstructure. As a result, remarkable hydrolysis activity and enduring stability are demonstrated. Our work exemplifies the use of a bioinspired supramolecular assembly approach to develop next-generation biocatalysts for biotechnological applications.",
keywords = "biocatalysis, nano-superstructure, peptide, self-assembly, supramolecular chemistry",
author = "Yu Chen and Yuqin Yang and Orr, {Asuka A.} and Pandeeswar Makam and Boris Redko and Elvira Haimov and Yannan Wang and Shimon, {Linda J.W.} and Sigal Rencus-Lazar and Meiting Ju and Phanourios Tamamis and Hao Dong and Ehud Gazit",
note = "Publisher Copyright: {\textcopyright} 2021 Wiley-VCH GmbH",
year = "2021",
month = jul,
day = "26",
doi = "10.1002/anie.202105830",
language = "אנגלית",
volume = "60",
pages = "17164--17170",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "31",
}