Self-assembled G4-DNA-silver nanoparticle structures

Irit Lubitz, Alexander Kotlyar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Here, we describe the preparation and properties of discrete conjugates between silver nanoparticles and G-quadruplex DNA. The 20 nm silver nanoparticles (AgNPs) were connected by G-quadruplexes containing phosphorothioate anchor residues at both ends of the DNA, and the resulting conjugates were separated on the basis of the number of nanoparticles by gel electrophoresis. The molecular morphology of discrete conjugates was confirmed by TEM analysis. We have shown that the absorption spectrum of the conjugates is broader than that of AgNPs not connected to each other, indicating the presence of plasmon-mediated interparticle interactions. We discuss possible application of the conjugates in nanoelectronics.

Original languageEnglish
Pages (from-to)482-487
Number of pages6
JournalBioconjugate Chemistry
Issue number3
StatePublished - 16 Mar 2011


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