@article{3c24df12ebc44aad89d22e857ecb6083,
title = "Selective Stepwise Arylation of Unprotected Peptides by PtIV Complexes",
abstract = "LPtIVF(Aryl) complexes bearing a bulky bidentate 2-[bis(adamant-1-yl)phosphino]phenoxide ligand (L) demonstrate excellent reactivity and selectivity in the arylation of X−H (X=S, N) bonds of amino acid residues in unprotected peptides under mild, including aqueous, conditions. Stepwise addition of these complexes allowed a convenient one-pot introduction of different aromatic groups in the X−H bonds of Cys and N terminus. PtIV reagents can also be used to further arylate N−H bonds in Lys and Trp providing access to peptides bearing multiple aromatic groups.",
keywords = "Arylation Reactions, Bioconjugation, Peptides, Platinum Complexes",
author = "Xiaoxi Lin and Elvira Haimov and Boris Redko and Arkadi Vigalok",
note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.",
year = "2022",
month = jul,
day = "18",
doi = "10.1002/anie.202205368",
language = "אנגלית",
volume = "61",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "29",
}