TY - JOUR
T1 - Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells
AU - Isaac, Roi
AU - Boura-Halfon, Sigalit
AU - Gurevitch, Diana
AU - Shainskaya, Alla
AU - Levkovitz, Yechiel
AU - Zick, Yehiel
PY - 2013/2/22
Y1 - 2013/2/22
N2 - Background: Selective serotonin reuptake inhibitors (SSRIs) are used for the treatment of mood and anxiety disorders. Results: SSRIs inhibit insulin action and secretion, promote the unfolded protein response, and induce apoptosis of pancreatic β cells. Conclusion: SSRIs inhibit insulin signaling and beta cell function. Significance: SSRIs might accelerate the transition from an insulin-resistant state to overt diabetes.
AB - Background: Selective serotonin reuptake inhibitors (SSRIs) are used for the treatment of mood and anxiety disorders. Results: SSRIs inhibit insulin action and secretion, promote the unfolded protein response, and induce apoptosis of pancreatic β cells. Conclusion: SSRIs inhibit insulin signaling and beta cell function. Significance: SSRIs might accelerate the transition from an insulin-resistant state to overt diabetes.
UR - http://www.scopus.com/inward/record.url?scp=84874297756&partnerID=8YFLogxK
U2 - 10.1074/jbc.M112.408641
DO - 10.1074/jbc.M112.408641
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:84874297756
SN - 0021-9258
VL - 288
SP - 5682
EP - 5693
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 8
ER -
