■ BACKGROUND AND OBJECTIVE: To assess the efficacy and safety of selective laser trabeculoplasty (SLT) in uncontrolled pseudoexfoliation glaucoma (PEXG). ■ PATIENTS AND METHODS: Fifty-seven eyes (57 patients) with uncontrolled PEXG and intraocular pressure (IOP) greater than 23 mm Hg underwent SLT. All received ophthalmic evaluation preoperatively and at intervals postoperatively. IOP was measured at 1 hour, 1 day, 1 week, and 1, 3, 6, and 12 months postoperatively. During follow-up, patients were treated with topical anti-glaucoma medications as necessary. ■ RESULTS: One year postoperatively, mean IOP in all patients decreased from 26.01 ± 2.5 to 17.8 ± 2.8 mm Hg (31.5%; P < .001). Mean medications per patient decreased from 2.8 to 2.3. Complications included conjunctival redness and infection within 1 day postoperatively in 30 eyes (67%). One hour after SLT treatment, an increase in IOP greater than 5 mm Hg was detected in two eyes (3.5%) and resolved within 24 hours with topical medication. ■ CONCLUSION: SLT is safe and effective in patients with PEXG.