TY - JOUR
T1 - Selective inference in complex research
AU - Benjamini, Yoav
AU - Heller, Ruth
AU - Yekutieli, Daniel
PY - 2009/11/13
Y1 - 2009/11/13
N2 - We explain the problem of selective inference in complex research using a recently published study: a replicability study of the associations in order to reveal and establish risk loci for type 2 diabetes. The false discovery rate approach to such problems will be reviewed, and we further address two problems: (i) setting confidence intervals on the size of the risk at the selected locations and (ii) selecting the replicable results. This journal is
AB - We explain the problem of selective inference in complex research using a recently published study: a replicability study of the associations in order to reveal and establish risk loci for type 2 diabetes. The false discovery rate approach to such problems will be reviewed, and we further address two problems: (i) setting confidence intervals on the size of the risk at the selected locations and (ii) selecting the replicable results. This journal is
KW - False coverage rate
KW - False discovery rate
KW - Genome-wise association scan
KW - Multiple comparisons
KW - Replicability
UR - http://www.scopus.com/inward/record.url?scp=73349090866&partnerID=8YFLogxK
U2 - 10.1098/rsta.2009.0127
DO - 10.1098/rsta.2009.0127
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C2 - 19805444
AN - SCOPUS:73349090866
SN - 1364-503X
VL - 367
SP - 4255
EP - 4271
JO - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
JF - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
IS - 1906
ER -
