Selective inactivation of DNase II specific inhibitor of mouse liver, spleen, and kidney by heating and by acidic pH treatment

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Abstract

Crude and partially purified preparations of DNase II from mouse liver, spleen, and kidney contain a DNase II specific inhibitor. The inhibitor is selectively inactivated by a low pH treatment and heating while DNase II is very resistant to these treatments. Activation of DNase II achieved by removing the inhibitor was highest in the kidney and lowest in the liver. The inhibitor is not dialyzable and can be inactivated by pronase digestion.

Original languageEnglish
Pages (from-to)196-204
Number of pages9
JournalEnzyme
Volume17
Issue number3
DOIs
StatePublished - 1974

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