Selection: A server for detecting evolutionary forces at a single amino-acid site

Research output: Contribution to journalArticlepeer-review

Abstract

Summary: We present an algorithmic tool for the identification of biologically significant amino acids in proteins of known three dimensional structure. We estimate the degree of purifying selection and positive Darwinian selection at each site and project these estimates onto the molecular surface of the protein. Thus, patches of functional residues (undergoing either positive or purifying selection), which may be discontinuous in the linear sequence, are revealed. We test for the statistical significance of the site-specific scores in order to obtain reliable and valid estimates.

Original languageEnglish
Pages (from-to)2101-2103
Number of pages3
JournalBioinformatics
Volume21
Issue number9
DOIs
StatePublished - 1 May 2005

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