Seizure control and treatment in pregnancy: Observations from the EURAP epilepsy pregnancy registry

Torbjörn Tomson*, D. Battino, E. Bonizzoni, J. Craig, D. Lindhout, E. Perucca, A. Sabers, F. Vajda, M. J. Brodie, B. Schmidt, F. Faravelli, R. Finnell, S. Messina, B. Moche, S. Ratti, A. Erba, D. Giavoni, L. Prato, S. Kochen, G. LuefK. Ten Berg, A. De Marinis, D. Vitezic, J. Zarubova, R. Kuba, M. Dahl, R. Kälviäinen, M. Beaussart, L. Sturua, O. Toidze, B. Schmitz, P. Kwan, G. Barcs, S. V. Thomas, M. Neufeld, D. Mamoli, M. Tanaka, R. Mameniskiene, G. Kiteva-Trencevska, K. O. Nakken, W. Liao, J. Jedrzejczak, A. Guekht, O. Lokshina, A. Russell, D. Sokic, V. Safcak, B. Cebular, M. Martinez Ferri, H. Baier, B. Tettenborn, C. W. Lai, Özkara, G. Escaray, C. Baumgartner, M. Feichtinger, M. Graf, M. Hamberger, M. Nagler, A. Hitchcock, J. Graham, R. Beran, S. Berkovic, A. Black, M. Cook, J. Dunne, N. Lawn, P. Silbert, C. Kilpatrick, T. O’brien, C. Lander, D. McLaughlin, E. Somerville, P. Boon, K. Vonck, C. Asmad, D. Sepic-Grahovac, M. Brázdil, I. Novotná, I. Tyrlíková, H. Krijtova, I. Nemcova, D. Tislerova, H. Vacovska, J. Alving, V. Stubbings, J. Arentsen, J. Tørring, B. A’ Rogvi Hansen, G. Gulliksen, B. Pedersen, P. Sidenius, T. Sørensen, M. Worm, S. Rainesalo, R. Roivanen, A. Salmivaara, S. Kasradze, I. Coban, V. Gaus, R. Kretz, M. Bacher, B. Steinhoff, D. Dennig, N. Füratsch, B. Müffelmann, U. Specht, F. Wörmann, H. Hamer, F. Rosenow, A. Jung, A. Kumar, R. Röbling, Y. Weber, B. S. Kasper, F. Kerling, M. Lindenau, A. Schwenkhagen, S. Stodieck, H. J. Meencke, J. Pandian, U. Aguglia, C. Albano, G. Ambrosetto, F. Bisulli, L. Antonini, G. De Maria, G. Battaglia, M. De Curtis, R. Biondi, V. Sofia, G. Bogliun, M. Bondavalli, R. Campostrini, M. Casazza, S. Franceschetti, A. Citernesi, P. D'alessandro, E. Gallinella, G. De Agazio, A. La Neve, M. R. de Feo, N. Foschi, A. Ortenzi, A. Paggi, A. Franza, C. Palmieri, K. Turner, C. Fumarola, C. Gregori, M. Vinci, C. A. Galimberti, R. Manni, R. Galli, R. Rocchi, A. Gambardella, A. Labate, A. Ganga, P. G. Garofalo, M. Panozzo, L. Guidolin, C. Labate, A. M. Papantonio, L. M. Specchio, A. Pistelli, M. Prugger, M. L. Vaccario, G. Zaccara, M. Zadra, M. Zucconi, K. Fukushima, M. Watanabe, M. Sasagawa, V. Jaskeviciene, E. Cvetkovska, A. J. Bader, C. A. van Donselaar, D. Lambrechts, A. van Oppen, D. Aurlien, G. Brathen, E. Brodtkorb, B. Engelsen, T. B. Hauge, K. M. Lillestølen, R. Lossius, K. Oekseter, T. Svendsen, E. Taubøll, W. Telstad, L. Cabral-Lim, Y. X. Liu, E. Arthur, R. Duncan, J. Greene, I. Hamill, J. P. Leach, S. Yule, P. Parker, M. Ercegovac, N. Vojvodic, G. Toncev, S. Vujisic, N. Jovic, D. Castro Vilanova, P. de la Peña Mayor, T. Escartin, M. Forcadas Berdusan, J. Galan, M. L. Galiano, A. Gil-Nagel, M. Martin Moro, E. Pastor, I. Perez Lopez-Fraile, B. Borre, L. Brattström, K. Carlheim Gyllensköld, P. de Flon, J. Hägglund, A. K. Wärme, I. Hämberg, H. Karlsson, E. Kumlien, B. Wiksten, A. M. Landtblom, B. Söderfeldt, U. Lindbom, H. Lindsten, A. Lundgren, K. Malmgren, G. Ekstedt, A. Nilsson, R. Palm, L. Sjöström, L. Stridh, S. Zemguliené, B. Theander, J. Toft, A. M. Torstensson, L. Wallrup, T. Y. Chang, D. Atakli, H. Misirli, S. Velioglu, N. Yeni

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To analyze seizure control and treatment in pregnant women with epilepsy. Methods: Seizure control and treatment were recorded prospectively in 1,956 pregnancies of 1,882 women with epilepsy participating in EURAP, an international antiepileptic drugs (AEDs) and pregnancy registry. Results: Of all cases, 58.3% were seizure-free throughout pregnancy. Occurrence of any seizures was associated with localization-related epilepsy (OR: 2.5; 1.7 to 3.9) and polytherapy (OR: 9.0; 5.6 to 14.8) and for tonic-clonic seizures, with oxcarbazepine monotherapy (OR: 5.4; 1.6 to 17.1). Using first trimester as reference, seizure control remained unchanged throughout pregnancy in 63.6%, 92.7% of whom were seizure-free during the entire pregnancy. For those with a change in seizure frequency, 17.3% had an increase and 15.9% a decrease. Seizures occurred during delivery in 60 pregnancies (3.5%), more commonly in women with seizures during pregnancy (OR: 4.8; 2.3 to 10.0). There were 36 cases of status epilepticus (12 convulsive), which resulted in stillbirth in one case but no cases of miscarriage or maternal mortality. AED treatment remained unchanged in 62.7% of the pregnancies. The number or dosage of AEDs were more often increased in pregnancies with seizures (OR: 3.6; 2.8 to 4.7) and with monotherapy with lamotrigine (OR: 3.8; 2.1 to 6.9) or oxcarbazepine (OR: 3.7; 1.1 to 12.9). Conclusions: The majority of patients with epilepsy maintain seizure control during pregnancy. The apparently higher risk of seizures among women treated with oxcarbazepine and the more frequent increases in drug load in the oxcarbazepine and lamotrigine cohorts prompts further studies on relationships with pharmacokinetic changes. Risks associated with status epilepticus appear to be lower than previously reported.

AdverseEffects:No adverse effects were mentioned.

Original languageEnglish
Pages (from-to)354-360
Number of pages7
JournalNeurology
Volume66
Issue number3
DOIs
StatePublished - 1 Feb 2006
Externally publishedYes

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