Sedation effect on temporary threshold shift induced by acoustic overstimulation

Minka Hildesheimer*, Yael Henkin, Chava Muchnik, Rachel Anafi, Emma Sahartov, Moshe Rubinstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The mechanism by which noise damages the inner ear has not as yet been fully elucidated. Experiments were done to study the influence of the sedation in temporary threshold shift (TS) induced by acoustic overstimulation, as barbiturates were found to improve the brain's tolerance to ischemia. Four groups of guinea pigs (GP) were used. The temporary TS was decreased with the reduction of the temperature in awake, as well as sedated, sound-exposed GP. However, the temporary TS in the sedated, but normothermic GP was as great as in the awake, normothermic group. The high temperature counteracts the protection effect of the sedation in noise-induced hearing loss.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalHearing Research
Issue number1
StatePublished - Jan 1991


  • Sedation
  • Temperature
  • Temporary threshold shift


Dive into the research topics of 'Sedation effect on temporary threshold shift induced by acoustic overstimulation'. Together they form a unique fingerprint.

Cite this