TY - JOUR
T1 - Sedation effect on temporary threshold shift induced by acoustic overstimulation
AU - Hildesheimer, Minka
AU - Henkin, Yael
AU - Muchnik, Chava
AU - Anafi, Rachel
AU - Sahartov, Emma
AU - Rubinstein, Moshe
PY - 1991/1
Y1 - 1991/1
N2 - The mechanism by which noise damages the inner ear has not as yet been fully elucidated. Experiments were done to study the influence of the sedation in temporary threshold shift (TS) induced by acoustic overstimulation, as barbiturates were found to improve the brain's tolerance to ischemia. Four groups of guinea pigs (GP) were used. The temporary TS was decreased with the reduction of the temperature in awake, as well as sedated, sound-exposed GP. However, the temporary TS in the sedated, but normothermic GP was as great as in the awake, normothermic group. The high temperature counteracts the protection effect of the sedation in noise-induced hearing loss.
AB - The mechanism by which noise damages the inner ear has not as yet been fully elucidated. Experiments were done to study the influence of the sedation in temporary threshold shift (TS) induced by acoustic overstimulation, as barbiturates were found to improve the brain's tolerance to ischemia. Four groups of guinea pigs (GP) were used. The temporary TS was decreased with the reduction of the temperature in awake, as well as sedated, sound-exposed GP. However, the temporary TS in the sedated, but normothermic GP was as great as in the awake, normothermic group. The high temperature counteracts the protection effect of the sedation in noise-induced hearing loss.
KW - Sedation
KW - Temperature
KW - Temporary threshold shift
UR - http://www.scopus.com/inward/record.url?scp=0026024608&partnerID=8YFLogxK
U2 - 10.1016/0378-5955(91)90014-Z
DO - 10.1016/0378-5955(91)90014-Z
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AN - SCOPUS:0026024608
SN - 0378-5955
VL - 51
SP - 161
EP - 166
JO - Hearing Research
JF - Hearing Research
IS - 1
ER -