Securing the immune tightrope: Mononuclear phagocytes in the intestinal lamina propria

Chen Varol, Ehud Zigmond, Steffen Jung*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The intestinal landscape comprises the host's own tissue and immune cells, as well as a diverse intestinal microbiota. Intricate regulatory mechanisms have evolved to maintain peaceful coexistence at this site, the breakdown of which can result in devastating inflammatory bowel diseases (IBDs). Mononuclear phagocytes promote both innate and adaptive immune responses in the gut and, as such, are essential for the maintenance of intestinal homeostasis. Here, we review the origins and functions of the mononuclear phagocytes found in the intestinal lamina propria, highlighting the problems that have arisen from their classification. Understanding these cells in their physiological context will be important for developing new therapies for IBDs.

Original languageEnglish
Pages (from-to)415-426
Number of pages12
JournalNature Reviews Immunology
Issue number6
StatePublished - May 2010
Externally publishedYes


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