Secondary cancers after bone marrow transplantation

Michael Lishner, Ruth Lang, Robert P. Witherspoon, Lloyd D. Fisher, Keith M. Sullivan, Rainer Storb, E. Donnall Thomas

Research output: Contribution to journalLetterpeer-review

2 Scopus citations


To the Editor: Witherspoon et al. (Sept. 21 issue)1 analyzed the incidence of secondary cancers after bone marrow transplantation. Although they discuss the role of immunosuppression in the pathogenesis of secondary cancers, they provide no information about the relative risk in patients who underwent allogeneic bone marrow transplantation as compared with that in patients who underwent autologous or syngeneic transplantation. Since immunologic disorders after allogeneic bone marrow transplantation, including acute and chronic graft-versus-host disease, are often severe, and immunosuppressive treatment is frequently required, we would expect the incidence of secondary malignant tumors to be higher in recipients of allogeneic bone.

Original languageEnglish
Pages (from-to)853
Number of pages1
JournalNew England Journal of Medicine
Issue number12
StatePublished - 22 Mar 1990
Externally publishedYes


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