TY - JOUR
T1 - Secondary cancers after bone marrow transplantation
AU - Lishner, Michael
AU - Lang, Ruth
AU - Witherspoon, Robert P.
AU - Fisher, Lloyd D.
AU - Sullivan, Keith M.
AU - Storb, Rainer
AU - Thomas, E. Donnall
PY - 1990/3/22
Y1 - 1990/3/22
N2 - To the Editor: Witherspoon et al. (Sept. 21 issue)1 analyzed the incidence of secondary cancers after bone marrow transplantation. Although they discuss the role of immunosuppression in the pathogenesis of secondary cancers, they provide no information about the relative risk in patients who underwent allogeneic bone marrow transplantation as compared with that in patients who underwent autologous or syngeneic transplantation. Since immunologic disorders after allogeneic bone marrow transplantation, including acute and chronic graft-versus-host disease, are often severe, and immunosuppressive treatment is frequently required, we would expect the incidence of secondary malignant tumors to be higher in recipients of allogeneic bone.
AB - To the Editor: Witherspoon et al. (Sept. 21 issue)1 analyzed the incidence of secondary cancers after bone marrow transplantation. Although they discuss the role of immunosuppression in the pathogenesis of secondary cancers, they provide no information about the relative risk in patients who underwent allogeneic bone marrow transplantation as compared with that in patients who underwent autologous or syngeneic transplantation. Since immunologic disorders after allogeneic bone marrow transplantation, including acute and chronic graft-versus-host disease, are often severe, and immunosuppressive treatment is frequently required, we would expect the incidence of secondary malignant tumors to be higher in recipients of allogeneic bone.
UR - http://www.scopus.com/inward/record.url?scp=0025712643&partnerID=8YFLogxK
U2 - 10.1056/NEJM199003223221216
DO - 10.1056/NEJM199003223221216
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C2 - 2308621
AN - SCOPUS:0025712643
SN - 0028-4793
VL - 322
SP - 853
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 12
ER -