Seborrheic skin and acne vulgaris as protective factors against the development of basal cell epithelioma

R. Friedman-Birnbaum*, S. Linn, T. Eidlitz-Markus, Y. Harth, E. Cohen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


This study was conducted in order to evaluate a possible protective role of seborrheic complexion and a history of acne on the development of basal cell epithelioma (BCE). For this purpose, 77 patients with this tumor were examined and asked to fill out a questionnaire. The questionnaire included demographic data and questions about skin type, eye and hair colors, sun exposure habits and a past history of acne. The nature, number and location of tumors, the texture of skin and acne scars were noted by a physician. A group of 93 age-, sex- and skin-color-matched patients served as controls. The results show a clear relationship between seborrheic features and a lower risk of developing BCE, after controlling for solar exposure using the Mantel-Haenszel summary measure. The same trend was found in patients with a history of acne. Whether ultraviolet light absorption by sebum, an anticancer activity of Propionibacterium acnes or other factors play a protective role against the development of BCE is as yet unclear.

Original languageEnglish
Pages (from-to)160-163
Number of pages4
Issue number3
StatePublished - 1991
Externally publishedYes


  • acne
  • basal cell epithelioma
  • protective factors
  • seborrhea


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