Seaweed cellulose scaffolds derived from green macroalgae for tissue engineering

Nurit Bar-Shai*, Orna Sharabani-Yosef*, Meiron Zollmann, Ayelet Lesman*, Alexander Golberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Extracellular matrix (ECM) provides structural support for cell growth, attachments and proliferation, which greatly impact cell fate. Marine macroalgae species Ulva sp. and Cladophora sp. were selected for their structural variations, porous and fibrous respectively, and evaluated as alternative ECM candidates. Decellularization–recellularization approach was used to fabricate seaweed cellulose-based scaffolds for in-vitro mammalian cell growth. Both scaffolds were confirmed nontoxic to fibroblasts, indicated by high viability for up to 40 days in culture. Each seaweed cellulose structure demonstrated distinct impact on cell behavior and proliferation rates. The Cladophora sp. scaffold promoted elongated cells spreading along its fibers’ axis, and a gradual linear cell growth, while the Ulva sp. porous surface, facilitated rapid cell growth in all directions, reaching saturation at week 3. As such, seaweed-cellulose is an environmentally, biocompatible novel biomaterial, with structural variations that hold a great potential for diverse biomedical applications, while promoting aquaculture and ecological agenda.

Original languageEnglish
Article number11843
JournalScientific Reports
Issue number1
StatePublished - Dec 2021


FundersFunder number
Aron Frenkel Air Pollution Initiative Center
Israel Water Authority
Israel Water Authority and Aron Frenkel Center
United States-Israel Binational Science Foundation20171292
Tel Aviv University


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