Screening for colorectal neoplasia: A multicenter study in Israel

H. S. Odes, P. Rozen, E. Ron, D. Bass, L. Bat, S. Keren, Z. Fireman, E. Shemesh, P. Krugliak, G. Fraser, M. Golan, J. Krawiec

Research output: Contribution to journalArticlepeer-review

Abstract

We report the design and results of thc first Israeli multicenter screening program for colorectal neoplasia. The screening protocol comprised a risk questionnaire, fecal occult blood testing, flexible sigmoidoscopy and colonoscopy. A total of 5,601 individuals were screened in five medical centers, 55% being asymptomatic with low or average risk. Colorectal tumors were found in 12.3% of screenees, the majority being adenomas. The risk for large bowel neoplasia was greatest in persons with a personal history of colorectal neoplasia (neoplasia rate 473.2/103) and was increased in those with inflammatory bowel disease, a family history of colorectal tumor, or past history of cured breast cancer. European-born Jews had a 50% greater risk than non-European-born Jews. Persons at high risk were more likely to return for repeat screening than those at low or average risk. However, approximately 15% of persons at high risk actually thought that they were of average risk. Fecal occult blood testing was markedly less reliable than flexible sigmoidoscopy and had a false-negative rate of 84.4%. The results demonstrate that existing medical facilities in Israel can be used to screen at least those individuals with increased risk for colorectal neoplasia.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalIsrael Journal of Medical Sciences
Volume28
Issue number1 SUPPL.
StatePublished - 1992
Externally publishedYes

Keywords

  • Colon cancer
  • Colonoscopy
  • Colorectal neoplasia
  • HEMOCCULT®
  • Multicenter study
  • Screening
  • Sigmoidoscopy

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