Scleredema adultorum associated with IgG‐kappa multiple myeloma–a case report and review of the literature

The coexistence of monoclonal gammopathy with scleredema is an already known but unusual finding. However, the association of scleredema with multiple myeloma has only rarely been reported. A case of widespread longstanding scleredema is presented in which the finding of monoclonal gammopathy subsequently progressed to oven IgG‐kappa multiple myeloma. From a review of the literature, it was concluded that scleredema patients having monoclonal gammopathy with or without multiple myeloma, share a number of clinical and laboratory features: (1) a widespread long‐standing eruption; (2) no preceding upper respiratory tract infection and usually without accompanying diabetes mellitus; (3) most commonly identified paraprotein is IgG having a kappa light chain. It is suggested that scleredema should be included in the list of diseases related to monoclonal gammopathy, the latter either denoting monoclonal gammopathy of undetermined significance or representing an already existing or incipient multiple myeloma.