Schizophrenic neutrophils inflammatory responses: parallel studies of chemotaxis, superoxide release and bactericidal activity

P. Sirota, R. Gavrieli, B. Epstein, B. Wolach

Research output: Contribution to journalArticlepeer-review

Abstract

Recently some authors have reported defective neutrophil phagocytosis in schizophrenic patients. There are several lines of evidence to support the contributions of oxygen free radicals to schizophrenia including lipid peroxidation in patients' "blood," increased breath pentane and carbon disulfide, alterations in blood levels of antioxidant enzymes, and increased fatty acids. Objective: To investigate neutrophil function in schizophrenic patients. Methods: Eighteen schizophrenic patients (DSMIV) and 15 healthy controls were studied. Neutrophil responses of phagocytosis, chemotaxis and Superoxide release were investigated. Results: A significant statistical increase of Superoxide anion release was found in schizophrenic patients as compared to controls (mean+SEM, patients: 6.89±0.30 nmol 02-/106 cells/min, controls: 5.13±0.55 nmol 02-/106 cells/min, p=0.015). We were unable to detect differences in chemotaxis and phagocytosis between healthy controls and schizophrenic patients. Conclusions: In schizophrenic patients there is over production of free radicals. Further studies are required to establish the role of oxidative stress in ethipathogenesis of schizophrenia.

Original languageEnglish
Pages (from-to)71
Number of pages1
JournalIsrael Journal of Psychiatry and Related Sciences
Volume38
Issue number1
StatePublished - 2001
Externally publishedYes

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