Schistosoma japonicum migration through mouse skin compared histologically and immunologically with S. mansoni

Lin Wang, Yong Long Li, Zvi Fishelson, John R. Kusel, Andreas Ruppel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The migration of Schistosoma japonicum and S. mansoni through mouse skin epidermis and dermis was compared by immunofluorescence techniques from 4 to 22 h after infection. At all times, the percentage of parasites detected in the dermis was significantly higher for S. japonicum than for S. mansoni. Thus, S. japonicum migrates more rapidly very early after infection. This agrees with the quicker migration observed previously by this species for later times. Both species expressed antigens related to the cercarial glycocalyx on the parasite body and antigenically detectable elastase in the acetabular glands, at least until 22 h after infection. Bot sets of antigens were also left as "traces" in cercarial migration channels in the skin as well as in skin tissue in the absence of detectable worms or migration channels. The data further substantiate differences between schistosome species in the speed of migration, and suggest that glycocalyx-related antigens and cercarial elastase continue to be expressed for at least 1 day after infection.

Original languageEnglish
Pages (from-to)218-223
Number of pages6
JournalParasitology Research
Volume95
Issue number3
DOIs
StatePublished - Feb 2005

Funding

FundersFunder number
National Council for Forest Research and Development
Deutscher Akademischer Austauschdienst
Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg
Ministry of Science and Technology, Israel

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