Schilder's disease: Non-invasive diagnosis and successful treatment with human immunoglobulins

Dror Kraus*, Osnat Konen, Rachel Straussberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Schilder's disease (SD) is a rare variant of multiple sclerosis with a predilection to children. It is characterized by focal neurological abnormalities, which are atypical for MS, in conjunction with tumor-like white matter lesions on MRI. We report the case of an 11-year-old girl that demonstrates two important features of the disease: a) the clinical presentation and subsequent course in conjunction with the serial neuroradiological findings stress the feasibility of a non-invasive diagnosis of SD; and b) we report a significant clinical response to treatment with intravenous human Immunoglobulins.

Original languageEnglish
Pages (from-to)206-208
Number of pages3
JournalEuropean Journal of Paediatric Neurology
Issue number2
StatePublished - Mar 2012


  • Human immunoglobulin treatment
  • Multiple sclerosis variants
  • Pediatric multiple sclerosis
  • Schilder's disease


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