TY - JOUR
T1 - Schilder's disease
T2 - Non-invasive diagnosis and successful treatment with human immunoglobulins
AU - Kraus, Dror
AU - Konen, Osnat
AU - Straussberg, Rachel
PY - 2012/3
Y1 - 2012/3
N2 - Schilder's disease (SD) is a rare variant of multiple sclerosis with a predilection to children. It is characterized by focal neurological abnormalities, which are atypical for MS, in conjunction with tumor-like white matter lesions on MRI. We report the case of an 11-year-old girl that demonstrates two important features of the disease: a) the clinical presentation and subsequent course in conjunction with the serial neuroradiological findings stress the feasibility of a non-invasive diagnosis of SD; and b) we report a significant clinical response to treatment with intravenous human Immunoglobulins.
AB - Schilder's disease (SD) is a rare variant of multiple sclerosis with a predilection to children. It is characterized by focal neurological abnormalities, which are atypical for MS, in conjunction with tumor-like white matter lesions on MRI. We report the case of an 11-year-old girl that demonstrates two important features of the disease: a) the clinical presentation and subsequent course in conjunction with the serial neuroradiological findings stress the feasibility of a non-invasive diagnosis of SD; and b) we report a significant clinical response to treatment with intravenous human Immunoglobulins.
KW - Human immunoglobulin treatment
KW - Multiple sclerosis variants
KW - Pediatric multiple sclerosis
KW - Schilder's disease
UR - http://www.scopus.com/inward/record.url?scp=84857362142&partnerID=8YFLogxK
U2 - 10.1016/j.ejpn.2011.07.010
DO - 10.1016/j.ejpn.2011.07.010
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C2 - 21925910
AN - SCOPUS:84857362142
SN - 1090-3798
VL - 16
SP - 206
EP - 208
JO - European Journal of Paediatric Neurology
JF - European Journal of Paediatric Neurology
IS - 2
ER -