Wounds and wound healing are parts of every organism's life. What is a wound, how does it heal and what can we do to speed the healing, but decrease scarring? All these fundamental questions occupy the minds of people through all known history. Wound healing is an extremely complex phenomenon, which involves both the organism and its environment. Moreover, chemical, biological, mechanical and electrical forces drive this phenomenon. This chapter attempts to combine various aspects of wound healing phenomena with an emphasis on scarless regeneration. The system approach to wound healing is needed to develop new therapies. This chapter starts with the general overview on what is a wound from the system perspective. Then it describes the highlevel events that take place during normal and abnormal wound healing. Next, it gives a historic perceptive on the history of wound healing in humans. Then it describes the fundamentals of scar biology, going to the details of known biochemical and cellular events involved in the process of scar formation. It then deals with the mechanical and electrical events that affect wound healing process. Next, complex events such as inflammation and wound-bacteria interaction are discussed, followed by descriptions of the in vitro and in vivo models of scarless wound healing. This chapter concludes with open questions and future perspectives of scarless wound healing.