SARS-CoV-2 outbreak in a synagogue community: Longevity and strength of anti-SARS-CoV-2 IgG responses

Yael Gozlan, Stephen Reingold, Ravit Koren, Osnat Halpern, Gili Regev-Yochay, Carmit Cohen, Asaf Biber, Orit Picard, Ella Mendelson, Yaniv Lustig, Orna Mor

Research output: Contribution to journalArticlepeer-review

Abstract

SARS-CoV-2 pandemic is still ongoing along with the global vaccination efforts against it. Here we aimed to understand the longevity and strength of anti-SARS-CoV-2 IgG responses in a small community (n=283) six months following local SARS-COV-2 outbreak in March 2020. Three serological assays were compared and neutralization capability was also determined. Overall 16.6% (47/283) of the participants were seropositive and 89.4% (42/47) of the IgG positives had neutralizing antibodies. Most of the symptomatic individuals confirmed as PCR positive during the outbreak were seropositive (30/32, 93.8%) and 33.3% of the individuals who quarantined with a PCR confirmed patient had antibodies. Serological (DiaSorin) targeting the S protein and ELISA targeting RBD detected 9.5% (27/283), 17.3% (49/283) and 17% (48/283), respectively, as IgG positives. The latter two assays highly agreed (kappa=0.89) between each other. In addition, 95%, (19/20, by ELISA) and 90.9% (20/22, with LIASON) and only 71.4% (15/21, by Architect) of individuals that were seropositive in May 2020 were found positive also in September. The unexpected low rate of overall immunity indicates absence of un-noticed, asymptomatic infections. Lack of overall high correlation between the assays is attributed mainly to target-mediated antibody responses and suggests that using a single serological assay may be misleading.

Original languageEnglish
JournalEpidemiology and Infection
DOIs
StateAccepted/In press - 2021

Keywords

  • Herd immunity
  • Igg antibodies
  • Neutralizing antibodies
  • Sars-cov-2
  • Sero-prevalence

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