SARS-CoV-2 antibody dynamics among kidney transplant recipients 3 months after BNT162b2 vaccination: A prospective cohort study

Dana Yelin, Benaya Rozen-Zvi*, Dafna Yahav, Naomi Ben-Dor, Tali Steinmetz, Timna Agur, Boris Zingerman, Shira Schneider, Shelly Lichtenberg, Haim Ben-Zvi, Tiki Mashraki, Ruth Rahamimov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Data regarding immunogenicity of mRNA severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines among kidney transplant recipients in the months following vaccination are lacking. We aimed to investigate humoral immune response at 3-4 months post-vaccination among a cohort of kidney transplant recipients, compared with a control group of dialysis patients. Anti-spike antibodies were tested at 1 and 3-4 months after vaccination. Of 259 kidney transplant recipients tested at a median time of 110 days from second vaccine dose, 99 (38%) were seropositive, compared with 83% (101/122) of control patients. Younger age, better renal function and lower immunosuppression levels were associated with seropositivity. A total of 14% (13/94) of participants seropositive at 1 month became seronegative at follow-up and 11% (18/165) became seropositive. The latter were mainly individuals with higher antibody levels at 1 month. Antibody levels at 3-4 months were significantly reduced in both study groups, although the decline was more pronounced in the control group. Kidney transplant recipients present poor antibody response to mRNA SARS-CoV-2 vaccination, with only 38% seropositive at 3-4 months. Nevertheless, the decay in antibody response over time is modest, and some patients may present delayed response, reaching adequate antibody levels at 3-4 months. Low seropositivity rates in this group call for investigating other immunization strategies.

Original languageEnglish
Pages (from-to)992-998
Number of pages7
JournalCKJ: Clinical Kidney Journal
Volume15
Issue number5
DOIs
StatePublished - 1 May 2022

Keywords

  • COVID-19
  • antibodies
  • immune response
  • kidney transplant
  • mRNA vaccine

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