TY - JOUR
T1 - Sarcopenia and Cognitive Decline in Hospitalized Older Adults from a Prospective Study
AU - Kon-Kfir, Sapir
AU - Cukierman-Yaffe, Tali
AU - Krupkin, Haim
AU - Belkin, Ana
AU - Shlomai, Gadi
AU - Bleier, Jonathan
AU - Weinstein, Shiri
AU - Bruckmayer, Liora
AU - Prinz, Elad
AU - Kaplan, Alon
AU - Shraga, Michal Goldenberg
AU - Lev, Dana
AU - Dekel, Shahar
AU - Shalmon, Noa
AU - Tsarfaty, Nurit
AU - Reiss, Niv
AU - Bischof, Evelyne
AU - Leibowitz, Avshalom
N1 - Publisher Copyright:
© 2025 Kon-Kfir S. et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License
PY - 2026/2/1
Y1 - 2026/2/1
N2 - As populations age, sarcopenia increasingly impacts healthcare due to its associations with morbidity, mortality, and cognitive decline. This study is a cross-sectional analysis of prospectively collected data from 140 older adults hospitalized in an internal medicine department. Sarcopenia was measured by handgrip strength, and cognitive function by the Digit Symbol Substitution Test (DSST). Sarcopenic patients (n=78) had lower DSST scores (p=0.003) and Norton scores (P< 0.001) compared to non-sarcopenic patients. Handgrip strength showed a significant positive correlation with DSST scores (R=0.26, p=0.0019), persisting after adjustments for age and sex (R=0.42, p=1.7e-07). This study underscores a significant association between sarcopenia and cognitive decline in hospitalized older adults, advocating for routine sarcopenia and cognitive assessments upon admission. These findings emphasize the importance of identifying at-risk patients early and developing targeted interventions. Future research should further explore underlying mechanisms and validate findings in broader cohorts.
AB - As populations age, sarcopenia increasingly impacts healthcare due to its associations with morbidity, mortality, and cognitive decline. This study is a cross-sectional analysis of prospectively collected data from 140 older adults hospitalized in an internal medicine department. Sarcopenia was measured by handgrip strength, and cognitive function by the Digit Symbol Substitution Test (DSST). Sarcopenic patients (n=78) had lower DSST scores (p=0.003) and Norton scores (P< 0.001) compared to non-sarcopenic patients. Handgrip strength showed a significant positive correlation with DSST scores (R=0.26, p=0.0019), persisting after adjustments for age and sex (R=0.42, p=1.7e-07). This study underscores a significant association between sarcopenia and cognitive decline in hospitalized older adults, advocating for routine sarcopenia and cognitive assessments upon admission. These findings emphasize the importance of identifying at-risk patients early and developing targeted interventions. Future research should further explore underlying mechanisms and validate findings in broader cohorts.
KW - agility
KW - aging
KW - clinical stamina assessment
KW - frailty
KW - grip strength
UR - https://www.scopus.com/pages/publications/105026692586
U2 - 10.14336/AD.2024.1676
DO - 10.14336/AD.2024.1676
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C2 - 40153579
AN - SCOPUS:105026692586
SN - 2152-5250
VL - 17
SP - 578
EP - 587
JO - Aging and Disease
JF - Aging and Disease
IS - 1
ER -